| Cell line name |
Rh28/L-PAM |
|---|
| Synonyms |
Rh28 L-PAM; Rh28/LPAM; RH28/LPAM; Rh 28/LPAM; Rh28 PX11/LPAM; Rh-28 PX11/LPAM |
|---|
| Accession |
CVCL_Y584 |
|---|
| Resource Identification Initiative |
To cite this cell line use: Rh28/L-PAM (RRID:CVCL_Y584) |
|---|
| Comments |
Selected for resistance to: ChEBI; CHEBI_28876; Melphalan (L-phenylalanine mustard; LPAM; Alkeran).
Derived from site: Metastatic; Axillary lymph node; UBERON=UBERON_0001097. |
|---|
| Sequence variations |
- Gene fusion; HGNC; HGNC:3819; FOXO1 + HGNC; HGNC:8617; PAX3; Name(s)=PAX3-FOXO1, PAX3-FKHR (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Heterozygous (from parent cell line).
|
|---|
| Disease |
Alveolar rhabdomyosarcoma (NCIt: C3749)
Alveolar rhabdomyosarcoma (ORDO: Orphanet_99756) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_8752 (Rh28) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
17Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=2890432
Julie K. Horton, Peter J. Houghton, Janet A. Houghton;
Reciprocal cross-resistance in human rhabdomyosarcomas selected in vivo for primary resistance to vincristine and L-phenylalanine mustard.
Cancer Res. 47:6288-6293(1987) PubMed=23882450; DOI=10.3389/fonc.2013.00183; PMCID=PMC3713458
Ashley R.P. Hinson, Rosanne Jones, Lisa E.S. Crose, Brian C. Belyea, Frederic G. Barr, Corinne Mary Linardic;
Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.
Front. Oncol. 3:183.1-183.12(2013) PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Beverly A. Teicher, Eric C. Polley, Mark W. Kunkel, David Evans, Thomas E. Silvers, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly ...Show all 14 authors... , Erik Harris, Anne Monks, Joel Morris; Show fewer authors
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015) |
|---|
| Cross-references |
|---|
| Encyclopedic resources |
Wikidata; Q54950337
|
|---|
| Gene expression databases |
GEO; GSM1676360
GEO; GSM1701690
|
|---|
| Entry history |
|---|
| Entry creation | 10-Apr-2015 |
|---|
| Last entry update | 19-Dec-2024 |
|---|
| Version number | 13 |
|---|
