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Cellosaurus HG-3 (CVCL_Y547)

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Cell line name HG-3
Synonyms HG3
Accession CVCL_Y547
Resource Identification Initiative To cite this cell line use: HG-3 (RRID:CVCL_Y547)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Characteristics: Genetically heterogeneous, consists of 3 subclones (PubMed=27566572).
Doubling time: ~50-70 hours (DSMZ=ACC-765).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
HLA typing Source: DSMZCellDive=ACC-765
Class I
HLA-AA*11:01:01,31:01:02
HLA-BB*07:02:01,15:01:01
HLA-CC*03:03:01,07:02:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:02:01,04:01:01
HLA-DQDQA1*01:02:01,01:04:01
DQB1*05:03:01,06:02:01
HLA-DRDRA*01:01:01,01:02:03
DRB1*14:54:01,15:01:01
Disease Chronic lymphocytic leukemia (NCIt: C3163)
B-cell chronic lymphocytic leukemia (ORDO: Orphanet_67038)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 70Y
Category Transformed cell line
STR profile Source(s): DepMap=ACH-001520; DSMZ=ACC-765

Markers:
AmelogeninX,Y
CSF1PO11,14
D2S133817
D3S135817,18
D5S81811
D7S8208,13
D8S117911,15
D13S31711,13
D16S5399,12
D18S5114,16
D19S43315,16
D21S1129,30
FGA23,24
Penta D9,10
Penta E11,12
TH017,9.3
TPOX8,12
vWA17,20

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Publications

PubMed=22720208; DOI=10.4161/onci.1.1.18400; PMCID=PMC3376971
Anders Rosen, Ann-Charlotte Bergh, Peter Gogolak, Chamilly Evaldsson, Anna Lanemo Myhrinder, Eva Hellqvist, Abu Rasul, Magnus Bjorkholm, Mattias Jansson, Larry Mansouri, An-Quan Liu ...Show all 14 authors... , Bin Tean Teh, Richard Rosenquist, Eva Klein; Show fewer authors
Lymphoblastoid cell line with B1 cell characteristics established from a chronic lymphocytic leukemia clone by in vitro EBV infection.
OncoImmunology 1:18-27(2012)

PubMed=23297799; DOI=10.3109/10428194.2013.764418
Anna Lanemo Myhrinder, Eva Hellqvist, Ann-Charlotte Bergh, Mattias Jansson, Kenneth Nilsson, Per Hultman, Jon Jonasson, Anne Mette Buhl, Lone Bredo Pedersen, Jesper Jurlander, Eva Klein ...Show all 15 authors... , Nicole Weit, Marco Herling, Richard Rosenquist, Anders Rosen; Show fewer authors
Molecular characterization of neoplastic and normal 'sister' lymphoblastoid B-cell lines from chronic lymphocytic leukemia.
Leuk. Lymphoma 54:1769-1779(2013)

PubMed=27566572; DOI=10.18632/oncotarget.11524; PMCID=PMC5325377
Hilmar Quentmeier, Claudia Pommerenke, Ole Ammerpohl, Robert Geffers, Vivien Hauer, Roderick A.F. MacLeod, Stefan Nagel, Julia Romani, Emanuela Rosati, Anders Rosen, Cord C. Uphoff ...Show all 13 authors... , Margarete Zaborski, Hans Gunther Drexler; Show fewer authors
Subclones in B-lymphoma cell lines: isogenic models for the study of gene regulation.
Oncotarget 7:63456-63465(2016)

PubMed=28489572; DOI=10.18632/oncotarget.17246; PMCID=PMC5522089
Maria Russo, Alfonsina Milito, Carmela Spagnuolo, Virginia Carbone, Anders Rosen, Paola Minasi, Fabio Lauria, Gian Luigi Russo;
CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia.
Oncotarget 8:42571-42587(2017)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-765
Cell line databases/resources Cell_Model_Passport; SIDM01817
DepMap; ACH-001520
DSMZCellDive; ACC-765
Encyclopedic resources Wikidata; Q54883310
Gene expression databases ArrayExpress; E-MTAB-4527
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
Entry history
Entry creation07-Nov-2014
Last entry update10-Apr-2025
Version number16