Publications | PubMed=23039195; DOI=10.1186/1756-6606-5-35; PMCID=PMC3546866 Imaizumi Y., Okada Y., Akamatsu W., Koike M., Kuzumaki N., Hayakawa H., Nihira T., Kobayashi T., Ohyama M., Sato S., Takanashi M., Funayama M., Hirayama A., Soga T., Hishiki T., Suematsu M., Yagi T., Ito D., Kosakai A., Hayashi K., Shouji M., Nakanishi A., Suzuki N., Mizuno Y., Mizushima N., Amagai M., Uchiyama Y., Mochizuki H., Hattori N., Okano H. Mitochondrial dysfunction associated with increased oxidative stress and alpha-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol. Brain 5:35.1-35.13(2012) PubMed=24389010; DOI=10.1016/j.neuron.2013.10.053 Bundo M., Toyoshima M., Okada Y., Akamatsu W., Ueda J., Nemoto-Miyauchi T., Sunaga F., Toritsuka M., Ikawa D., Kakita A., Kato M., Kasai K., Kishimoto T., Nawa H., Okano H., Yoshikawa T., Kato T., Iwamoto K. Increased L1 retrotransposition in the neuronal genome in schizophrenia. Neuron 81:306-313(2014) PubMed=24936452; DOI=10.1016/j.stemcr.2014.03.007; PMCID=PMC4050482 Numasawa-Kuroiwa Y., Okada Y., Shibata S., Kishi N., Akamatsu W., Shoji M., Nakanishi A., Oyama M., Osaka H., Inoue K., Takahashi K., Yamanaka S., Kosaki K., Takahashi T., Okano H. Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes. Stem Cell Reports 2:648-661(2014) PubMed=26056228; DOI=10.1093/hmg/ddv212 Ohta E., Nihira T., Uchino A., Imaizumi Y., Okada Y., Akamatsu W., Takahashi K., Hayakawa H., Nagai M., Ohyama M., Ryo M., Ogino M., Murayama S., Takashima A., Nishiyama K., Mizuno Y., Mochizuki H., Obata F., Okano H. I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling pathway. Hum. Mol. Genet. 24:4879-4900(2015) PubMed=28052261; DOI=10.1016/j.celrep.2016.12.020 Hosoya M., Fujioka M., Sone T., Okamoto S., Akamatsu W., Ukai H., Ueda H.R., Ogawa K., Matsunaga T., Okano H. Cochlear cell modeling using disease-specific iPSCs unveils a degenerative phenotype and suggests treatments for congenital progressive hearing loss. Cell Rep. 18:68-81(2017) PubMed=29179815; DOI=10.7554/eLife.21114; PMCID=PMC5705211 Okuno H., Renault-Mihara F., Ohta S., Fukuda K., Kurosawa K., Akamatsu W., Sanosaka T., Kohyama J., Hayashi K., Nakajima K., Takahashi T., Wysocka J.K., Kosaki K., Okano H. CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations. eLife 6:e21114.1-e21114.26(2017) PubMed=30127392; DOI=10.1038/s41591-018-0140-5 Fujimori K., Ishikawa M., Otomo A., Atsuta N., Nakamura R., Akiyama T., Hadano S., Aoki M., Saya H., Sobue G., Okano H. Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent. Nat. Med. 24:1579-1589(2018) |