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Cellosaurus WIL2:RD1694 (CVCL_Y425)

[Text version]
Cell line name WIL2:RD1694
Accession CVCL_Y425
Resource Identification Initiative To cite this cell line use: WIL2:RD1694 (RRID:CVCL_Y425)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_5847; ICI D1694 (Tomudex; ZD1694).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6544 (WIL2)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
Publications

PubMed=7537518; DOI=10.1038/bjc.1995.178; PMCID=PMC2033796
Ann L. Jackman, Lloyd R. Kelland, Rosemary Kimbell, Margaret Brown, William Gibson, G. Wynne Aherne, Anthea Hardcastle, Francis Thomas Boyle;
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Br. J. Cancer 71:914-924(1995)

Cross-references
Encyclopedic resources Wikidata; Q54994069
Entry history
Entry creation07-Nov-2014
Last entry update10-Apr-2025
Version number13