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Cellosaurus SKOV3/VP (CVCL_Y280)

[Text version]
Cell line name SKOV3/VP
Accession CVCL_Y280
Resource Identification Initiative To cite this cell line use: SKOV3/VP (RRID:CVCL_Y280)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line

PubMed=7911742; DOI=10.1007/BF00685075
Kubota N., Nishio K., Takeda Y., Ohmori T., Funayama Y., Ogasawara H., Ohira T., Kunikane H., Terashima Y., Saijo N.
Characterization of an etoposide-resistant human ovarian cancer cell line.
Cancer Chemother. Pharmacol. 34:183-190(1994)

PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2
Yasui K., Mihara S., Zhao C., Okamoto H., Saito-Ohara F., Tomida A., Funato T., Yokomizo A., Naito S., Imoto I., Tsuruo T., Inazawa J.
Alteration in copy numbers of genes as a mechanism for acquired drug resistance.
Cancer Res. 64:1403-1410(2004)

Cell line databases/resources cancercelllines; CVCL_Y280
CGH-DB; 9125-4
Encyclopedic resources Wikidata; Q54954774
Entry history
Entry creation07-Nov-2014
Last entry update05-Oct-2023
Version number17