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Cellosaurus K562/AC (CVCL_Y198)

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Cell line name K562/AC
Accession CVCL_Y198
Resource Identification Initiative To cite this cell line use: K562/AC (RRID:CVCL_Y198)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28680; Cytarabine (Arabinosylcytosine; Ara-C).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=10781689; DOI=10.1016/S0145-2126(00)00016-3
Tadao Funato, Junko Satou, Yuko Nishiyama, Shinichi Fujimaki, Toshihiko Miura, Mitsuo Kaku, Takeshi Sasaki;
In vitro leukemia cell models of Ara-C resistance.
Leuk. Res. 24:535-541(2000)

PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2
Kohichiroh Yasui, Saori Mihara, Chen Zhao, Hiroyuki Okamoto, Fumiko Saito-Ohara, Akihiro Tomida, Tadao Funato, Akira Yokomizo, Seiji Naito, Issei Imoto, Takashi Tsuruo, Johji Inazawa;
Alteration in copy numbers of genes as a mechanism for acquired drug resistance.
Cancer Res. 64:1403-1410(2004)

Cross-references
Cell line databases/resources CGH-DB; 9121-4
Encyclopedic resources Wikidata; Q54899402
Entry history
Entry creation07-Nov-2014
Last entry update19-Dec-2024
Version number18