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Cellosaurus VU1149+SV40+DDX11 (CVCL_XX29)

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Cell line name VU1149+SV40+DDX11
Synonyms DDX11+
Accession CVCL_XX29
Resource Identification Initiative To cite this cell line use: VU1149+SV40+DDX11 (RRID:CVCL_XX29)
Comments Genetic integration: Method=Transfection; Gene=HGNC; HGNC:2736; DDX11.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Cell type: Fibroblast; CL=CL_0000057.
Disease Warsaw breakage syndrome (NCIt: C164675)
Warsaw breakage syndrome (ORDO: Orphanet_280558)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_XX30 ! VU1149+SV40+pcDNA
Category Transformed cell line
Publications

PubMed=26423134; DOI=10.1038/ncomms9399; PMCID=PMC4600715
Job de Lange, Atiq Faramarz, Anneke B. Oostra, Renee X. de Menezes, Ida H. van der Meulen, Martin A. Rooimans, Davy A.P. Rockx, Ruud H. Brakenhoff, Victor W. van Beusechem, Randall W. King, Johan P. de Winter, Rob M.F. Wolthuis;
Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.
Nat. Commun. 6:8399.1-8399.12(2015)

Cross-references
Encyclopedic resources Wikidata; Q98134598
Entry history
Entry creation19-Dec-2019
Last entry update14-Aug-2025
Version number9