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Cellosaurus VU1199-F SV40 (CVCL_XX26)

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Cell line name VU1199-F SV40
Synonyms VU1199 + SV40; ESCO2-
Accession CVCL_XX26
Resource Identification Initiative To cite this cell line use: VU1199-F SV40 (RRID:CVCL_XX26)
Comments Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:27230; ESCO2; Simple; p.Arg293Serfs*7 (c.877_878AG[1]) (c.877_878delAG); ClinVar=VCV000021251; Zygosity=Homozygous (from parent cell line).
Disease Roberts syndrome (NCIt: C126326)
Roberts syndrome (ORDO: Orphanet_3103)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_XX25 (VU1199-F)
Children:
CVCL_XX27 (VU1199-F SV40+GFP-ESCO2)CVCL_XX28 (VU1199-F SV40+V5-ESCO2)
Sex of cell Male
Age at sampling 2M
Category Transformed cell line
Publications

PubMed=19738907; DOI=10.1371/journal.pone.0006936; PMCID=PMC2734174
Petra van der Lelij, Barbara C. Godthelp, Wouter van Zon, Djoke van Gosliga, Anneke B. Oostra, Jurgen Steltenpool, Jan de Groot, Riekeld J. Scheper, Rob M.F. Wolthuis, Quinten Waisfisz, Firouz Darroudi ...Show all 13 authors... , Hans Joenje, Johan P. de Winter; Show fewer authors
The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2.
PLoS ONE 4:e6936.1-e6936.11(2009)

PubMed=26423134; DOI=10.1038/ncomms9399; PMCID=PMC4600715
Job de Lange, Atiq Faramarz, Anneke B. Oostra, Renee X. de Menezes, Ida H. van der Meulen, Martin A. Rooimans, Davy A.P. Rockx, Ruud H. Brakenhoff, Victor W. van Beusechem, Randall W. King, Johan P. de Winter, Rob M.F. Wolthuis;
Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.
Nat. Commun. 6:8399.1-8399.12(2015)

Cross-references
Encyclopedic resources Wikidata; Q98134605
Entry history
Entry creation19-Dec-2019
Last entry update14-Aug-2025
Version number10