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Cellosaurus OHSU-974 (CVCL_XX23)

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Cell line name OHSU-974
Synonyms OHSU-0974; OHSU974; OHSU-SCC-974
Accession CVCL_XX23
Resource Identification Initiative To cite this cell line use: OHSU-974 (RRID:CVCL_XX23)
Comments Caution: TP53 mutation indicated to be at p.Asp41fs (c.121delT) in PubMed=15735012.
Caution: The 8 loci STR profile in PubMed=36912284 supp. table is incorrect and is that of NCI-H1299. The correct and extended (16 loci) profile is shown in this entry thanks to a personal communication of Wakefield, Leslie.
Sequence variations
Disease Fanconi anemia, complementation group A (NCIt: C125702)
Tongue squamous cell carcinoma (NCIt: C4648)
Fanconi anemia (ORDO: Orphanet_84)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 29Y
Category Cancer cell line
STR profile Source(s): PubMed=36912284

Markers:
AmelogeninX
CSF1PO10
D3S135816
D5S81812,13
D7S82013
D8S117910,13
D13S3179
D16S5399,11
D18S5113
D21S1131.2,33.2
FGA21,22.2
Penta D11,13
Penta E11,12
TH017,9
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=15735012; DOI=10.1158/0008-5472.CAN-04-3665
Hester J.T. van Zeeburg, Peter J.F. Snijders, Gerard Pals, Mario A.J.A. Hermsen, Martin A. Rooimans, Grover Carlton Bagby, Jean Soulier, Eliane Gluckman, Johan Wennerberg, C. Rene Leemans, Hans Joenje, Ruud H. Brakenhoff;
Generation and molecular characterization of head and neck squamous cell lines of Fanconi anemia patients.
Cancer Res. 65:1271-1276(2005)

PubMed=23613873; DOI=10.1371/journal.pone.0061555; PMCID=PMC3629194
Sanne R. Martens-de Kemp, Simone U. Dalm, Fiona M.J. Wijnolts, Arjen Brink, Richard J. Honeywell, Godefridus Johannes Peters, Boudewijn J.M. Braakhuis, Ruud H. Brakenhoff;
DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.
PLoS ONE 8:e61555.1-e61555.9(2013)

PubMed=25609062; DOI=10.1158/1078-0432.CCR-14-2616; PMCID=PMC4401632
Anne J. Lombardi, Elizabeth E. Hoskins, Grant D. Foglesong, Kathryn A. Wikenheiser-Brokamp, Lisa Wiesmuller, Helmut Hanenberg, Paul R. Andreassen, Allison J. Jacobs, Susan B. Olson, Winifred W. Keeble, Laura E. Hays, Susanne I. Wells;
Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers.
Clin. Cancer Res. 21:1962-1972(2015)

PubMed=36912284; DOI=10.1002/ijc.34506
Hiep Tai Nguyen, Wei-Liang Tang, Andrew L.H. Webster, Jeffrey R. Whiteaker, Christopher M. Chandler, Ricardo Errazquin Ciudad, Khashayar Roohollahi, Madeline Fritzke, Elizabeth E. Hoskins, Erica C. Jonlin, Leslie Wakefield ...Show all 21 authors... , Lucas B. Sullivan, Eleanor Y. Chen, Josephine Christine Dorsman, Ruud H. Brakenhoff, Amanda Grace Paulovich, Markus Grompe, Ramon Garcia-Escudero, Susanne I. Wells, Agata Smogorzewska, Raymond J. Monnat Jr.; Show fewer authors
Fanconi anemia-isogenic head and neck cancer cell line pairs: a basic and translational science resource.
Int. J. Cancer 153:183-196(2023)

Cross-references
Cell line databases/resources cancercelllines; CVCL_XX23
Encyclopedic resources Wikidata; Q98128333
Polymorphism and mutation databases IARC_TP53; 21669
Entry history
Entry creation19-Dec-2019
Last entry update19-Dec-2024
Version number10