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Cellosaurus HAP1 TMEM106B (-) 3 (CVCL_XU38)

[Text version]
Cell line name HAP1 TMEM106B (-) 3
Synonyms HZGHC005877c010; TMEM106B knockout cell line 4bp deletion
Accession CVCL_XU38
Resource Identification Initiative To cite this cell line use: HAP1 TMEM106B (-) 3 (RRID:CVCL_XU38)
Comments Group: Haploid karyotype cell line.
Knockout cell: Method=CRISPR/Cas9; HGNC; 22407; TMEM106B.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y019 (HAP1)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Publications

PubMed=37545650; DOI=10.12688/f1000research.131333.1
Ayoubi R., Fotouhi M., Southern K., Bhajiawala R., Fanti R., Prinos P., McPherson P.S., Laflamme C.
The identification of high-performing antibodies for transmembrane protein 106B (TMEM106B) for use in western blot, immunoprecipitation, and immunofluorescence.
F1000Research 12:308.1-308.10(2023)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HZGHC005877c010
Cell line databases/resources cancercelllines; CVCL_XU38
Encyclopedic resources Wikidata; Q93973071
Entry history
Entry creation19-Dec-2019
Last entry update05-Oct-2023
Version number9