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Cellosaurus SAM-6 (CVCL_XI23)

[Text version]
Cell line name SAM-6
Synonyms SAM-6.10
Accession CVCL_XI23
Resource Identification Initiative To cite this cell line use: SAM-6 (RRID:CVCL_XI23)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2903.
Monoclonal antibody isotype: IgM.
Monoclonal antibody target: UniProtKB; P11021; Human HSPA5/GRP78 (isoform SAM-6).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_9V19 (HAB-1)
Category Hybridoma
Publications

PubMed=15173000; DOI=10.1158/0008-5472.CAN-03-3149
Pohle T., Brandlein S.U., Ruoff N., Muller-Hermelink H.-K., Vollmers H.P.
Lipoptosis: tumor-specific cell death by antibody-induced intracellular lipid accumulation.
Cancer Res. 64:3900-3906(2004)

PubMed=17237291; DOI=10.1158/1535-7163.MCT-06-0399
Brandlein S.U., Rauschert N., Rasche L., Dreykluft A., Hensel F., Conzelmann E., Muller-Hermelink H.-K., Vollmers H.P.
The human IgM antibody SAM-6 induces tumor-specific apoptosis with oxidized low-density lipoprotein.
Mol. Cancer Ther. 6:326-333(2007)

PubMed=18268478; DOI=10.1038/labinvest.2008.2
Rauschert N., Brandlein S.U., Holzinger E., Hensel F., Muller-Hermelink H.-K., Vollmers H.P.
A new tumor-specific variant of GRP78 as target for antibody-based therapy.
Lab. Invest. 88:375-386(2008)

Patent=WO2009104100A2
Vollmers H.P., Hensel F., Power B.E., Ilag L.L., Kelter A.-R., Schoenen F., Muller-Hermelink H.-K., Thalheimer A., Udabage L., Brandlein S.U.
Antibody combinations, and methods of making and using same.
Patent number WO2009104100A2, 27-Aug-2009

Patent=US9273125
Vollmers H.P.
Human monoclonal antibody having fat-reducing effect.
Patent number US9273125, 01-Mar-2016

Cross-references
Encyclopedic resources Wikidata; Q98129319
Entry history
Entry creation19-Dec-2019
Last entry update21-Mar-2023
Version number4