Cellosaurus cell line A2058-RFP/H2B-GFP (CVCL

Cellosaurus A2058-RFP/H2B-GFP (CVCL_XH73)

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Cell line name

A2058-RFP/H2B-GFP

Synonyms

A2058(RFP/H2B-GFP)

Accession

CVCL_XH73

Resource Identification Initiative

To cite this cell line use: A2058-RFP/H2B-GFP (RRID:CVCL_XH73)

Comments

Population: Caucasian.
Characteristics: The H2B-eGFP fusion construct is under the control of the pPGK promoter and localizes to the nucleus.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; PGG5S; tdTomato (Note=Bright red fluorescent protein derived from drFP583 (DsRed)).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:4761; H2BC11 (Note=With p.Gly26Asp and p.Ile119Val and fused in frame with eGFP).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Homozygous (from parent cell line).

Disease

Amelanotic melanoma (NCIt: C3802)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_1059 (A2058)
Children:

CVCL_XH74 (A2058-RFP/H2B-GFP BrM)

Sex of cell

Male

Age at sampling

43Y