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Cellosaurus MDA-MB-231sci (CVCL_XE60)

[Text version]
Cell line name MDA-MB-231sci
Accession CVCL_XE60
Resource Identification Initiative To cite this cell line use: MDA-MB-231sci (RRID:CVCL_XE60)
Comments Group: Patented cell line.
Group: Triple negative breast cancer (TNBC) cell line.
Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C200955.
Population: Caucasian.
Characteristics: Highly metastatic.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

Liu L., Yao M., Kong H.-W., Zhu Y.-X., Wang X.-M., Zhao F.-Y., Yan M.-X.
High metastasis human breast carcinoma cell subline and establishing method thereof.
Patent number CN102071168A, 25-May-2011

Cell line databases/resources CCRID; 4201PAT-CCTCC00312
Encyclopedic resources Wikidata; Q95987394
Entry history
Entry creation06-Sep-2019
Last entry update29-Jun-2023
Version number9