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Cellosaurus Hep3b-Cas9-743 (CVCL_XE53)

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Cell line name Hep3b-Cas9-743
Accession CVCL_XE53
Resource Identification Initiative To cite this cell line use: Hep3b-Cas9-743 (RRID:CVCL_XE53)
Comments Population: African American.
Characteristics: Transduced with a Cas9-FLAG-Neo construct.
Karyotypic information: Has lost chromosome Y.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9 (Note=With a C-terminal FLAG tag).
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:903; AXIN1; Simple; p.Arg146Ter (c.436C>T); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Ser576Ter (c.1727C>G); Zygosity=Homozygous (from parent cell line).
Disease Childhood hepatocellular carcinoma (NCIt: C7955)
Pediatric hepatocellular carcinoma (ORDO: Orphanet_33402)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0326 (Hep 3B2.1-7)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): CCRID=1101HUM-PUMC000743

Markers:
AmelogeninX
CSF1PO8
D2S133821,25
D3S135815
D5S81813
D6S104312,17
D7S8208
D8S117912
D12S39117
D13S31712,14
D16S53910
D18S5120
D19S43312.2,14
D21S1130,31
FGA18
Penta E5,16
TH016,7
TPOX9
vWA17

Run an STR similarity search on this cell line
Cross-references
Cell line databases/resources CCRID; 1101HUM-PUMC000743
Encyclopedic resources Wikidata; Q94102675
Entry history
Entry creation06-Sep-2019
Last entry update14-Aug-2025
Version number13