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Cellosaurus K562-Wnt5a (CVCL_XE50)

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Cell line name K562-Wnt5a
Accession CVCL_XE50
Resource Identification Initiative To cite this cell line use: K562-Wnt5a (RRID:CVCL_XE50)
Comments Group: Patented cell line.
Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C200958.
Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:12784; WNT5A.
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

Patent=CN101724603A
Jun Li, Zhao-Quan Li, Chang-Chun Niu, Jing Pan, Wei-Ke Si, Chen Zhao;
Transgenic cell K562-Wnt5a and preparation method thereof.
Patent number CN101724603A, 09-Jun-2010

PubMed=21069266; DOI=10.3892/ijmm.2010.560
Yuan Yuan, Chang-Chun Niu, Gang Deng, Zhao-Quan Li, Jing Pan, Chen Zhao, Zong-Lin Yang, Wei-Ke Si;
The Wnt5a/Ror2 noncanonical signaling pathway inhibits canonical Wnt signaling in K562 cells.
Int. J. Mol. Med. 27:63-69(2011)

Cross-references
Cell line databases/resources CCRID; 4201PAT-CCTCC00313
Encyclopedic resources Wikidata; Q94335728
Entry history
Entry creation06-Sep-2019
Last entry update14-Aug-2025
Version number14