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Cellosaurus MCF7-Cas9-543 (CVCL_XD69)

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Cell line name MCF7-Cas9-543
Accession CVCL_XD69
Resource Identification Initiative To cite this cell line use: MCF7-Cas9-543 (RRID:CVCL_XD69)
Comments Population: Caucasian.
Characteristics: Transduced with a Cas9-FLAG-Neo construct.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9 (Note=With a C-terminal FLAG tag).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): CCRID=1101HUM-PUMC000543

Markers:
AmelogeninX
CSF1PO10
D2S133821,23
D3S135816
D5S81811,12
D6S104312,18
D7S8208,9
D8S117910,14
D12S39118,20
D13S31711
D16S53911,12
D18S5114
D19S43313,14
D21S1130
FGA23,24,25
Penta E7,12
TH016
TPOX9,12
vWA14,15

Run an STR similarity search on this cell line
Cross-references
Cell line databases/resources cancercelllines; CVCL_XD69
CCRID; 1101HUM-PUMC000543
Encyclopedic resources Wikidata; Q95986788
Entry history
Entry creation06-Sep-2019
Last entry update14-Aug-2025
Version number14