Cellosaurus logo
expasy logo

Cellosaurus K8484 (CVCL_XD12)

[Text version]
Cell line name K8484
Accession CVCL_XD12
Resource Identification Initiative To cite this cell line use: K8484 (RRID:CVCL_XD12)
Comments Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Mutation; MGI; MGI:96680; Kras; Simple; p.Gly12Asp (c.35G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used).
  • Mutation; MGI; MGI:98834; Trp53; Simple; p.Arg270His (c.809G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used).
Disease Mouse pancreatic neoplasm (NCIt: C34035)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: LSL-KrasG12D:LSL-Trp53R270H:Pdx1-Cre (KPC).
Category Cancer cell line
STR profile Source(s): CRUK Cambridge RICS

Markers:
Mouse STR 1-110,16
Mouse STR 1-213
Mouse STR 2-19,16
Mouse STR 3-214
Mouse STR 4-218.3
Mouse STR 5-513,17
Mouse STR 6-417,18
Mouse STR 6-712,17
Mouse STR 7-129
Mouse STR 8-116
Mouse STR 11-214,15
Mouse STR 12-118
Mouse STR 13-116.2
Mouse STR 15-320.3
Mouse STR 17-212,16
Mouse STR 18-318
Mouse STR 19-213
Mouse STR X-126

Run an STR similarity search on this cell line
Publications

PubMed=19460966; DOI=10.1126/science.1171362; PMCID=PMC2998180
Kenneth P. Olive, Michael A. Jacobetz, Christian J. Davidson, Aarthi Gopinathan, Dominick McIntyre, Davina Jean Honess, Basetti Madhu, Mae A. Goldgraben, Meredith E. Caldwell, David Allard, Kristopher K. Frese ...Show all 37 authors... , Gina DeNicola, Christine Feig, Chelsea Combs, Stephen P. Winter, Heather Ireland-Zecchini, Stefanie Reichelt, William J. Howat, Alex Chang, Mousumi Dhara, Li-Fu Wang, Felix Ruckert, Robert Grutzmann, Christian Pilarsky, Kamel Izeradjene, Sunil R. Hingorani, Pearl Huang, Susan E. Davies, William Plunkett, Merrill Jon Egorin, Ralph H. Hruban, Nigel Whitebread, Karen McGovern, Julian Adams, Christine A. Iacobuzio-Donahue, John Griffiths, David Arthur Tuveson; Show fewer authors
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.
Science 324:1457-1461(2009)

Cross-references
Encyclopedic resources Wikidata; Q94336044
Entry history
Entry creation06-Sep-2019
Last entry update14-Aug-2025
Version number9