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Cellosaurus NCI-H1975-Cas9-595 (CVCL_XD03)

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Cell line name NCI-H1975-Cas9-595
Accession CVCL_XD03
Resource Identification Initiative To cite this cell line use: NCI-H1975-Cas9-595 (RRID:CVCL_XD03)
Comments Population: Caucasian.
Characteristics: Transduced with a Cas9-FLAG-Neo construct.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9 (Note=With a C-terminal FLAG tag).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1511 (NCI-H1975)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): CCRID=1101HUM-PUMC000595

Markers:
AmelogeninX
CSF1PO12
D2S133817
D3S135814,15
D5S81811,12
D7S8208
D8S117913
D12S39117
D13S31710,13
D16S5399,12
D18S5113
D19S43315,15.2
D21S1128
FGA21,24
Penta E12
TH017
TPOX8,11
vWA18

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Cross-references
Cell line databases/resources cancercelllines; CVCL_XD03
CCRID; 1101HUM-PUMC000595
Encyclopedic resources Wikidata; Q95993285
Entry history
Entry creation06-Sep-2019
Last entry update14-Aug-2025
Version number13