Cellosaurus MDA231-LeptoM (CVCL_XB00)
Cell line name | MDA231-LeptoM |
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Synonyms | MDA231 LeptoM; MDA-LeptoM |
Accession | CVCL_XB00 |
Resource Identification Initiative | To cite this cell line use: MDA231-LeptoM (RRID:CVCL_XB00) |
Comments | Group: Triple negative breast cancer (TNBC) cell line. Part of: Brain metastasis cell lines panel. Population: Caucasian. Characteristics: Brain leptomeningeal space metastatic derivative of parental cell line. Established after 3 passages in nude mice from intracisternal injection, followed by one passage from intracardiac injection and obtained from mice bearing leptomeningeal metastases. Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL). Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP). Transfected with: UniProtKB; P08659; Firefly luciferase. Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK. Omics: Transcriptome analysis by RNAseq. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
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Disease | Breast adenocarcinoma (NCIt: C5214) |
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
Hierarchy | Parent: CVCL_VR35 (MDA231-TGL) |
Sex of cell | Female |
Age at sampling | 51Y |
Category | Cancer cell line |
Web pages | https://apps.cnio.es/app/BrainMetastasis/CellLines |
Publications | PubMed=28283064; DOI=10.1016/j.cell.2017.02.025 |
Cross-references | |
Cell line databases/resources | cancercelllines; CVCL_XB00 |
Encyclopedic resources | Wikidata; Q95987482 |
Gene expression databases | GEO; GSM2194114
GEO; GSM2194115 |
Entry history | |
Entry creation | 06-Sep-2019 |
Last entry update | 05-Oct-2023 |
Version number | 11 |