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Cellosaurus HCC1954-LeptoM (CVCL_XA23)

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Cell line name HCC1954-LeptoM
Synonyms HCC1954 LeptoM
Accession CVCL_XA23
Resource Identification Initiative To cite this cell line use: HCC1954-LeptoM (RRID:CVCL_XA23)
Comments Part of: Brain metastasis cell lines panel.
Population: East Indian.
Characteristics: Brain leptomeningeal space metastatic derivative of parental cell line. Established after 3 passages in nude mice from intracisternal injection, followed by one passage from intracardiac injection and obtained from mice bearing leptomeningeal metastases.
Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL) and with PuroR/pac.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene fusion; HGNC; HGNC:2092; CLTC + HGNC; HGNC:29559; VMP1; Name(s)=CLTC-VMP1 (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Homozygous (from parent cell line).
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VR24 (HCC1954-TGL)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
Web pages Info; BrMPanel; -; https://apps.cnio.es/app/BrainMetastasis/CellLines
Publications

PubMed=28283064; DOI=10.1016/j.cell.2017.02.025; PMCID=PMC5405733
Adrienne Boire, Yi-Long Zou, Jason Shieh, Danilo G. Macalinao, Elena Pentsova, Joan Massague;
Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis.
Cell 168:1101-1113.e13(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_XA23
Encyclopedic resources Wikidata; Q93982608
Gene expression databases GEO; GSM2194092
GEO; GSM2194093
GEO; GSM2194094
Entry history
Entry creation06-Sep-2019
Last entry update14-Aug-2025
Version number14