Cellosaurus logo
expasy logo

Cellosaurus SAOS-alpha2beta1 (CVCL_X642)

[Text][XML][JSON]
Cell line name SAOS-alpha2beta1
Synonyms SAOS-a2b1
Accession CVCL_X642
Resource Identification Initiative To cite this cell line use: SAOS-alpha2beta1 (RRID:CVCL_X642)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6137; ITGA2.
Derived from site: In situ; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0548 (SaOS-2)
Sex of cell Female
Age at sampling 11Y
Category Cancer cell line
Publications

PubMed=10525544; DOI=10.1083/jcb.147.2.401; PMCID=PMC2174225
Johanna Ivaska, Hilkka Reunanen, Jukka Westermarck, Leeni Koivisto, Veli-Matti Kahari, Jyrki Heino;
Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail.
J. Cell Biol. 147:401-416(1999)

Cross-references
Anatomy/cell type resources BTO; BTO_0003778
Encyclopedic resources Wikidata; Q54952102
Entry history
Entry creation05-Sep-2014
Last entry update19-Dec-2024
Version number13