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Cellosaurus RCC52 (CVCL_X534)

[Text version]
Cell line name RCC52
Accession CVCL_X534
Resource Identification Initiative To cite this cell line use: RCC52 (RRID:CVCL_X534)
Comments Population: Chinese.
Doubling time: 23.4 hours (PubMed=24222125).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; HGNC:914; B2M; Simple; p.Ala6Profs*1 (c.16delG); Zygosity=Heterozygous (PubMed=18704411).
  • Mutation; HGNC; HGNC:914; B2M; Simple; p.Leu15Phefs*41 (c.43_44delCT); Zygosity=Heterozygous; Note=Total loss of HLA class 1 expression (PubMed=18704411).
HLA typing Source: PubMed=18704411
Class I
HLA-AA*02,11
HLA-BB*46,60(40)
HLA-CC*w01,w07
Disease Sarcomatoid renal cell carcinoma (NCIt: C27893)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=18704411; DOI=10.1007/s00262-008-0565-7; PMCID=PMC2793116
Hsieh C.-H., Hsu Y.-J., Chang C.-C., Liu H.-C., Chuang K.-L., Chuang C.-K., Pang S.-T., Hasumi K., Ferrone S., Liao S.-K.
Total HLA class I loss in a sarcomatoid renal carcinoma cell line caused by the coexistence of distinct mutations in the two encoding beta2-microglobulin genes.
Cancer Immunol. Immunother. 58:395-408(2009)

PubMed=24222125
Hsieh C.-H., Chen H.-C., Chang Y.-H., Pang S.-T., Kuo M.-L., Chuang C.-K., Liao S.-K.
Co-existence of epithelioid and fibroblastoid subsets in a sarcomatoid renal carcinoma cell line revealed by clonal studies.
Anticancer Res. 33:4875-4889(2013)

Cross-references
Encyclopedic resources Wikidata; Q54949468
Entry history
Entry creation05-Sep-2014
Last entry update19-Dec-2024
Version number13