| Cell line name |
U-2946 |
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| Accession |
CVCL_X503 |
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| Resource Identification Initiative |
To cite this cell line use: U-2946 (RRID:CVCL_X503) |
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| Comments |
Part of: LL-100 blood cancer cell line panel.
Doubling time: 48 hours (PubMed=27907212); ~20-30 hours (DSMZ=ACC-795).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
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| HLA typing |
Source: DSMZCellDive=ACC-795
| Class I | | HLA-A | A*01:01:01,02:01:01 | | HLA-B | B*35:01:01,52:01:01 | | HLA-C | C*04:01:01,12:02:02 | | Class II | | HLA-DP | DPA1*01:03:01,01:03:01 | | DPB1*04:02:01,02:01:02 | | HLA-DQ | DQA1*01:03:01,01:01:01 | | DQB1*05:01:01,06:01:01 | | HLA-DR | DRA*01:01:01,01:02:02 | | DRB1*01:01:01,15:02:01 |
|
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| Disease |
Diffuse large B-cell lymphoma activated B-cell type (NCIt: C36081)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Sex of cell |
Male |
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| Age at sampling |
52Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): DSMZ=ACC-795
Markers:| Amelogenin | X,Y |
| CSF1PO | 10,11 |
| D2S1338 | 20,24 |
| D3S1358 | 15,16 |
| D5S818 | 11,12 |
| D7S820 | 8,10 |
| D8S1179 | 10,14 |
| D13S317 | 11,12 |
| D16S539 | 11,12 |
| D18S51 | 11,17 |
| D19S433 | 12 |
| D21S11 | 30 |
| FGA | 20,23 |
| Penta D | 9 |
| Penta E | 11 |
| TH01 | 6,9.3 |
| TPOX | 9,12 |
| vWA | 17,18 |
Run an STR similarity search on this cell line |
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| Publications | PubMed=17926183; DOI=10.1080/10428190701636443
Marie Fridberg, Anna Servin, Lola Anagnostaki, Johan Linderoth, Mattias Berglund, Ola Soderberg, Gunilla Enblad, Anders Rosen, Tomas Mustelin, Mats Jerkeman, Jenny L. Persson, Anette Gjorloff Wingren;
Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.
Leuk. Lymphoma 48:2221-2232(2007) PubMed=27907212; DOI=10.1371/journal.pone.0167599; PMCID=PMC5132233
Hilmar Quentmeier, Hans Gunther Drexler, Vivien Hauer, Roderick A.F. MacLeod, Claudia Pommerenke, Cord C. Uphoff, Margarete Zaborski, Mattias Berglund, Gunilla Enblad, Rose-Marie Amini;
Diffuse large B cell lymphoma cell line U-2946: model for MCL1 inhibitor testing.
PLoS ONE 11:e0167599.1-e0167599.17(2016) PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019) |
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| Cross-references |
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| Cell line collections (Providers) |
DSMZ; ACC-795
|
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| Cell line databases/resources |
DSMZCellDive; ACC-795
|
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| Encyclopedic resources |
Wikidata; Q54973562
|
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| Gene expression databases |
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
|
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| Entry history |
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| Entry creation | 05-Sep-2014 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 19 |
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