Cellosaurus cell line EMC-BAC-2 (CVCL

Cellosaurus EMC-BAC-2 (CVCL_X487)

[Text version]

Cell line name

EMC-BAC-2

Synonyms

EMCBAC2

Accession

CVCL_X487

Resource Identification Initiative

To cite this cell line use: EMC-BAC-2 (RRID:CVCL_X487)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.

Sequence variations

Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Homozygous (Cosmic-CLP=1503370; DepMap=ACH-002102).
Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (Cosmic-CLP=1503370; DepMap=ACH-002102).

Genome ancestry

Source: PubMed=30894373

Origin	% genome
African	0.13
Native American	0
East Asian, North	1.05
East Asian, South	0
South Asian	0
European, North	72.26
European, South	26.55

Disease

Lung adenocarcinoma (NCIt: C3512)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Sex unspecified

Age at sampling

Age unspecified

Category

Cancer cell line

STR profile

Source(s): Cosmic-CLP=1503370

Markers:

Amelogenin	X
CSF1PO	10,11
D5S818	11,13
D7S820	7,9
D13S317	11,12
D16S539	10,12
TH01	6,9.3
TPOX	8,11
vWA	17

Publications

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_X487
Cell_Model_Passport; SIDM00047
Cosmic-CLP; 1503370
DepMap; ACH-002102

Chemistry resources

GDSC; 1503370
PharmacoDB; EMCBAC2_333_2019

Encyclopedic resources

Wikidata; Q54832280

Gene expression databases

ArrayExpress; E-MTAB-3610
GEO; GSM1669764

Proteomic databases

PRIDE; PXD030304

Sequence databases