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Cellosaurus 273T (CVCL_X482)

[Text version]
Cell line name 273T
Accession CVCL_X482
Resource Identification Initiative To cite this cell line use: 273T (RRID:CVCL_X482)
Comments From: Siegfried, Jill M.; University of Pittsburgh; Pittsburgh; USA.
Omics: Variations; SNP array analysis.
Miscellaneous: Age of donor from personal communication of Siegfried, Jill M.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Tyr727Cys (c.2180A>G); ClinVar= VCV001026153; Zygosity=Unspecified (PubMed=15735034).
Disease Lung squamous cell carcinoma (NCIt: C3493)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 88Y
Category Cancer cell line
Publications

PubMed=10545285; DOI=10.1006/pupt.1999.0210
Jill M. Siegfried, Nandigama Krishnamachary, Autumn L. Gaither Davis, Christopher T. Gubish, Jay D. Hunt, Sharon Persinger Shriver;
Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer.
Pulm. Pharmacol. Ther. 12:291-302(1999)

PubMed=15735034; DOI=10.1158/0008-5472.CAN-04-1872
Laura P. Stabile, Jennifer S. Lyker, Christopher T. Gubish, Wei-Ping Zhang, Jennifer Rubin Grandis, Jill M. Siegfried;
Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects.
Cancer Res. 65:1459-1470(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_X482
Encyclopedic resources Wikidata; Q54583760
Gene expression databases GEO; GSM784285
GEO; GSM827491
Polymorphism and mutation databases Cosmic; 910551
Progenetix; CVCL_X482
Entry history
Entry creation05-Sep-2014
Last entry update10-Apr-2025
Version number15