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Cellosaurus 201T (CVCL_X481)

[Text version]
Cell line name 201T
Accession CVCL_X481
Resource Identification Initiative To cite this cell line use: 201T (RRID:CVCL_X481)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
From: Siegfried, Jill M.; University of Pittsburgh; Pittsburgh; USA.
Population: African American.
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Miscellaneous: Age of donor from personal communication of Siegfried, Jill M.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser241Ala (c.721T>G); ClinVar=VCV000376665; Zygosity=Homozygous (Cosmic-CLP=1287381; DepMap=ACH-002089).
Genome ancestry Source: PubMed=30894373

Origin% genome
African88.81
Native American0
East Asian, North2.58
East Asian, South0
South Asian0
European, North3.06
European, South5.55
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1287381

Markers:
AmelogeninX,Y
CSF1PO7,13
D5S81812,13
D7S8209,10
D13S31711,13
D16S53911,12
TH017
TPOX6,8
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=9816093
Philip G. Kasprzyk, Terry L. Sullivan, Jay D. Hunt, Christopher T. Gubish, Cathy A. Scoppa, Mark Oelkuct, Robert E. Bird, Paul H. Fischer, Jill M. Siegfried, Charles Richter King;
Activity of anti-erbB-2 recombinant toxin OLX-209 on lung cancer cell lines in the absence of erbB-2 gene amplification.
Clin. Cancer Res. 2:75-80(1996)

PubMed=9816140
Nebojsa Skrepnik, Juan C. Araya, Zhong Qian, Hai-Bo Xu, John Hamide, Robertino Mera, Jay D. Hunt;
Effects of anti-erbB-2 (HER-2/neu) recombinant oncotoxin AR209 on human non-small cell lung carcinoma grown orthotopically in athymic nude mice.
Clin. Cancer Res. 2:1851-1857(1996)

PubMed=10545285; DOI=10.1006/pupt.1999.0210
Jill M. Siegfried, Nandigama Krishnamachary, Autumn L. Gaither Davis, Christopher T. Gubish, Jay D. Hunt, Sharon Persinger Shriver;
Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer.
Pulm. Pharmacol. Ther. 12:291-302(1999)

PubMed=15735034; DOI=10.1158/0008-5472.CAN-04-1872
Laura P. Stabile, Jennifer S. Lyker, Christopher T. Gubish, Wei-Ping Zhang, Jennifer Rubin Grandis, Jill M. Siegfried;
Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects.
Cancer Res. 65:1459-1470(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_X481
Cell_Model_Passport; SIDM00055
Cosmic-CLP; 1287381
DepMap; ACH-002089
Chemistry resources GDSC; 1287381
PharmacoDB; 201T_7_2019
Encyclopedic resources Wikidata; Q54583071
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827492
GEO; GSM1669564
Polymorphism and mutation databases Cosmic; 910550
Progenetix; CVCL_X481
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation05-Sep-2014
Last entry update10-Apr-2025
Version number25