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Cellosaurus MMH-D3 (CVCL_X374)

[Text version]
Cell line name MMH-D3
Synonyms MMH D3; D3; Met Murine Hepatocytes-D3
Accession CVCL_X374
Resource Identification Initiative To cite this cell line use: MMH-D3 (RRID:CVCL_X374)
Comments Genetic integration: Method=Transgenic mouse; Gene=HGNC; HGNC:7029; MET (Note=With p.Met1_Leu955del = cyto-Met).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Hepatocyte; CL=CL_0000182.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Sex of cell Sex unspecified
Age at sampling 3D
Category Spontaneously immortalized cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=MMH-D3
Publications

PubMed=9034332; DOI=10.1093/emboj/16.3.495; PMCID=PMC1169653
Laura Amicone, Francesca Maria Spagnoli, Gerald Frank Spath, Silvia Giordano, Cristina Tommasini, Silvia Bernardini, Veronica De Luca, Carlo Della Rocca, Mary C. Weiss, Paolo Maria Comoglio, Marco Tripodi;
Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes.
EMBO J. 16:495-503(1997)

PubMed=9817765; DOI=10.1083/jcb.143.4.1101; PMCID=PMC2132947
Francesca Maria Spagnoli, Laura Amicone, Marco Tripodi, Mary C. Weiss;
Identification of a bipotential precursor cell in hepatic cell lines derived from transgenic mice expressing cyto-Met in the liver.
J. Cell Biol. 143:1101-1112(1998)

PubMed=9828230; DOI=10.1002/hep.510280626
Alessandro Aiuti, Carla Cicchini, Silvia Bernardini, Giorgio Fedele, Laura Amicone, Antonio Fantoni, Marco Tripodi;
Hematopoietic support and cytokine expression of murine-stable hepatocyte cell lines (MMH).
Hepatology 28:1645-1654(1998)

PubMed=10457350; DOI=10.1002/(SICI)1097-4652(199910)181:1<24::AID-JCP3>3.0.CO;2-0
Diana Bellovino, Yeneisy Lanyau-Dominguez, Ivana Garaguso, Laura Amicone, Claudio Cavallari, Marco Tripodi, Sancia Gaetani;
MMH cells: an in vitro model for the study of retinol-binding protein secretion regulated by retinol.
J. Cell. Physiol. 181:24-32(1999)

Cross-references
Encyclopedic resources Wikidata; Q54906224
Entry history
Entry creation17-Jul-2014
Last entry update10-Apr-2025
Version number9