Cellosaurus logo
expasy logo

Cellosaurus CPEK (CVCL_WY80)

[Text version]
Cell line name CPEK
Synonyms Canine Progenitor Epidermal Keratinocyte
Accession CVCL_WY80
Resource Identification Initiative To cite this cell line use: CPEK (RRID:CVCL_WY80)
Comments Characteristics: Useful for investigating the immunopathogenesis of inflammatory skin diseases.
Doubling time: 14.8 +- 1.50 hours (PubMed=18772565).
Omics: Transcriptomics; Microarray.
Miscellaneous: Sex of donor from personal communication of Girling, Peter.
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Beagle; VBO=VBO_0200131.
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages Provider; CELLnTEC; -; https://cellntec.com/products/cpek
Publications

PubMed=18772565; DOI=10.1292/jvms.70.853
Sanae Shibata, Sadatoshi Maeda, Hiromi Tsuchida, Tsuneo Fukata;
Phenotypic analysis for a cell line of canine epidermal keratinocytes.
J. Vet. Med. Sci. 70:853-855(2008)

PubMed=20837364; DOI=10.1016/j.vetimm.2010.08.008
Sanae Shibata, Sadatoshi Maeda, Naho Kondo, Naoki Chimura, Akiko Inoue, Tsuneo Fukata;
Identification of the signaling pathway of TNF-alpha-induced CCL17/TARC transcription in a canine keratinocyte cell line.
Vet. Immunol. Immunopathol. 139:90-98(2011)

PubMed=20860556; DOI=10.1111/j.1365-3164.2010.00897.x
Sanae Shibata, Sadatoshi Maeda, Naho Kondo, Akiko Inoue, Shingo Maeda, Naoki Chimura, Tsuneo Fukata;
Effect of recombinant canine interferon-gamma on granulocyte-macrophage colony-stimulating factor, transforming growth factor-beta and CC chemokine ligand 17 mRNA transcription in a canine keratinocyte cell line (CPEK).
Vet. Dermatol. 22:24-30(2011)

PubMed=23067725; DOI=10.1016/j.vetmic.2012.09.017
Jenny Mullin, Stuart Carter, Nicola Williams, Neil McEwan, Tim Nuttall;
Transcription of canine Toll-like receptor 2, beta-defensin 1 and beta-defensin 103 in infected atopic skin, non-infected atopic skin, healthy skin and the CPEK cell line.
Vet. Microbiol. 162:700-706(2013)

PubMed=25190452; DOI=10.1186/s12917-014-0184-9; PMCID=PMC4172958
Lisa Y. Pang, Sally Anne Argyle, Ayako Kamida, Katherine O'Neill Morrison, David John Argyle;
The long-acting COX-2 inhibitor mavacoxib (Trocoxil TM) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells in vitro.
BMC Vet. Res. 10:184.1-184.11(2014)

PubMed=30268330; DOI=10.1016/j.tvjl.2018.09.001
Ryo Miyamoto, Sena Kurita, Hiroyuki Tani, Tomoyo Ikeda, Mio Ishizaka, Hono Saima, Masato Kobayashi, Kyoichi Tamura, Makoto Bonkobara;
Canine squamous cell carcinoma cell lines with high expression of survivin are sensitive to survivin inhibitor YM155.
Vet. J. 240:31-36(2018)

Cross-references
Encyclopedic resources Wikidata; Q93457518
Gene expression databases GEO; GSE77041
Entry history
Entry creation06-Sep-2019
Last entry update10-Apr-2025
Version number9