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Cellosaurus AT1BR (CVCL_WX69)

[Text version]
Cell line name AT1BR
Synonyms AT1Br; AT1 BR; Ataxia Telangiectasia 1 BRighton; BM0020
Accession CVCL_WX69
Resource Identification Initiative To cite this cell line use: AT1BR (RRID:CVCL_WX69)
Comments Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Ataxia telangiectasia syndrome (NCIt: C2887)
Ataxia telangiectasia (ORDO: Orphanet_100)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C1HN (AT1BR44neo)
Originate from same individual CVCL_ZT25 ! AT1BR LCL
Sex of cell Male
Age at sampling 7Y
Category Finite cell line
Publications

PubMed=2903889; DOI=10.1080/09553008814552321
Colin Francis Arlett, Michael H.L. Green, Anne Priestley, Susan A. Harcourt, Lynne V. Mayne;
Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes.
Int. J. Radiat. Biol. 54:911-928(1988)

PubMed=7836839; DOI=10.1080/09553009414551951
Jane Cole, Colin Francis Arlett;
Cloning efficiency and spontaneous mutant frequency in circulating T-lymphocytes in ataxia-telangiectasia patients.
Int. J. Radiat. Biol. 66:S123-S131(1994)

PubMed=10987302
Pierre-Marie Girard, Nicolas Foray, Markus Stumm, Alastair P.W. Waugh, Enriqueta Riballo, Richard S. Maser, William P. Phillips, John H.J. Petrini, Colin Francis Arlett, Penelope Ann Jeggo;
Radiosensitivity in Nijmegen breakage syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects.
Cancer Res. 60:4881-4888(2000)

PubMed=11452007; DOI=10.1091/mbc.12.7.2109; PMCID=PMC55660
Alessandra Montecucco, Rossella Rossi, Giovanni Ferrari, A. Ivana Scovassi, Ennio Prosperi, Giuseppe Biamonti;
Etoposide induces the dispersal of DNA ligase I from replication factories.
Mol. Biol. Cell 12:2109-2118(2001)

PubMed=12082606; DOI=10.1038/sj.onc.1205596
Pierre-Marie Girard, Enriqueta Riballo, Adrian C. Begg, Alastair P.W. Waugh, Penelope Ann Jeggo;
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest.
Oncogene 21:4191-4199(2002)

PubMed=15574327; DOI=10.1016/j.molcel.2004.10.029
Enriqueta Riballo, Martin Kuhne, Nicole Rief, Aidan J. Doherty, Graeme C.M. Smith, Maria-Jose Recio, Caroline Reis, Kirsten Dahm, Andreas Fricke, Andrea Krempler, Antony R. Parker ...Show all 15 authors... , Stephen Philip Jackson, Andrew R. Gennery, Penelope Ann Jeggo, Markus Lobrich; Show fewer authors
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Mol. Cell 16:715-724(2004)

PubMed=16714754; DOI=10.1259/bjr/83726649
Colin Francis Arlett, Piers N. Plowman, Paul Bryan Rogers, Christopher N. Parris, Fatemeh Abbaszadeh, Michael H.L. Green, Trevor J. McMillan, Cyd Bush, Nicolas Foray, Alan R. Lehmann;
Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum.
Br. J. Radiol. 79:510-517(2006)

PubMed=16874298; DOI=10.1038/sj.emboj.7601255; PMCID=PMC1553186
Aaron A. Goodarzi, Ya-Ping Yu, Enriqueta Riballo, Pauline Douglas, Sarah A. Walker, Rui-Qiong Ye, Christine Harer, Caterina Marchetti, Nick Morrice, Penelope Ann Jeggo, Susan P. Lees-Miller;
DNA-PK autophosphorylation facilitates Artemis endonuclease activity.
EMBO J. 25:3880-3889(2006)

PubMed=18079351; DOI=10.1259/bjr/27072321
Colin Francis Arlett, Michael H.L. Green, Paul Bryan Rogers, Alan R. Lehmann, Piers N. Plowman;
Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts.
Br. J. Radiol. 81:51-58(2008)

Cross-references
Encyclopedic resources Wikidata; Q93326280
Entry history
Entry creation06-Sep-2019
Last entry update29-Jun-2023
Version number6