Cellosaurus cell line BT320 (CVCL

Cellosaurus BT320 (CVCL_WW58)

Cross-references
Cell line name	BT320
Synonyms	BT 320; CPDM_1295X
Accession	CVCL_WW58
Resource Identification Initiative	To cite this cell line use: BT320 (RRID:CVCL_WW58)
Comments	Part of: Center for Patient Derived Models (CPDM) at Dana-Farber Cancer Institute cell line panel. Characteristics: Low-passage-number culture. Characteristics: Can grow as a neurosphere (PubMed=34610309). Omics: Genomics; Whole exome sequencing. Omics: Transcriptomics; RNAseq. Derived from site: In situ; Brain, right temporal cortex; UBERON=UBERON_0016538.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=27723727). Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (PubMed=27723727). Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly132Ala (c.395G>C); Zygosity=Unspecified (PubMed=27723727).
Disease	Glioblastoma, IDH-wildtype (NCIt: C39750) Glioblastoma (ORDO: Orphanet_360)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	74Y
Category	Cancer cell line
Web pages	Provider; CPDM; CPDM_1295X; https://docs.google.com/spreadsheets/d/1sxAPF3p6xK2h01zaiQ1ExCWwzhxeZ-oDLN3s3LeJq98/edit?usp=sharing
Publications	PubMed=27723727; DOI=10.1038/nbt.3697; PMCID=PMC5142231 Mark M. Stevens, Cecile L. Maire, Nigel Chou, Mark A. Murakami, David S. Knoff, Yuki Kikuchi, Robert J. Kimmerling, Hui-Yun Liu, Samer Haidar, Nicholas L. Calistri, Nathan Cermak ...Show all 18 authors... , Selim Olcum, Nicolas A. Cordero, Ahmed Idbaih, Patrick Yung-Chih Wen, David M. Weinstock, Keith Lloyd Ligon, Scott R. Manalis; Show fewer authors Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate. Nat. Biotechnol. 34:1161-1167(2016) PubMed=34610309; DOI=10.1016/j.celrep.2021.109788 Max A. Stockslager, Seth Malinowski, Mehdi Touat, Jennifer C. Yoon, Jack Geduldig, Mahnoor Mirza, Annette Sunhi Kim, Patrick Yung-Chih Wen, Kin-Hoe Chow, Keith Lloyd Ligon, Scott R. Manalis; Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models. Cell Rep. 37:109788.1-109788.12(2021)
Chemistry resources	PharmacoDB; BT320_134_2019
Encyclopedic resources	Wikidata; Q93432623
Entry history
Entry creation	06-Sep-2019
Last entry update	10-Apr-2025
Version number	9