Cellosaurus cell line BT179 (CVCL

Cellosaurus BT179 (CVCL_WW43)

Cross-references
Cell line name	BT179
Synonyms	BT 179; CPDM_1285X
Accession	CVCL_WW43
Resource Identification Initiative	To cite this cell line use: BT179 (RRID:CVCL_WW43)
Comments	Part of: Center for Patient Derived Models (CPDM) at Dana-Farber Cancer Institute cell line panel. Population: Caucasian. Characteristics: Low-passage-number culture. Characteristics: Can grow as a neurosphere (PubMed=34610309). Omics: Genomics; Whole exome sequencing. Omics: Genomics; Whole genome sequencing; Low read coverage. Omics: Transcriptomics; RNAseq. Derived from site: In situ; Brain, right parietal lobe; UBERON=UBERON_0002802.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile255Thr (c.764T>C); ClinVar=VCV000376623; Zygosity=Unspecified (PubMed=27723727).
Disease	Glioblastoma, IDH-wildtype (NCIt: C39750) Glioblastoma (ORDO: Orphanet_360)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	51Y
Category	Cancer cell line
Web pages	Provider; CPDM; CPDM_1285X; https://docs.google.com/spreadsheets/d/1sxAPF3p6xK2h01zaiQ1ExCWwzhxeZ-oDLN3s3LeJq98/edit?usp=sharing
Publications	PubMed=25184684; DOI=10.1371/journal.pone.0106694; PMCID=PMC4153667 Holmberg Olausson K., Maire C.L., Haidar S., Ling J., Learner E., Nister M., Ligon K.L. Prominin-1 (CD133) defines both stem and non-stem cell populations in CNS development and gliomas. PLoS ONE 9:e106694.1-e106694.11(2014) PubMed=27723727; DOI=10.1038/nbt.3697; PMCID=PMC5142231 Stevens M.M., Maire C.L., Chou N., Murakami M.A., Knoff D.S., Kikuchi Y., Kimmerling R.J., Liu H.-Y., Haidar S., Calistri N.L., Cermak N., Olcum S., Cordero N.A., Idbaih A., Wen P.Y.-C., Weinstock D.M., Ligon K.L., Manalis S.R. Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate. Nat. Biotechnol. 34:1161-1167(2016) PubMed=34610309; DOI=10.1016/j.celrep.2021.109788 Stockslager M.A., Malinowski S., Touat M., Yoon J.C., Geduldig J., Mirza M., Kim A.S., Wen P.Y.-C., Chow K.-H., Ligon K.L., Manalis S.R. Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models. Cell Rep. 37:109788.1-109788.12(2021)
Cell line databases/resources	cancercelllines; CVCL_WW43
Chemistry resources	PharmacoDB; BT179_122_2019
Encyclopedic resources	Wikidata; Q93432586
Entry history
Entry creation	06-Sep-2019
Last entry update	10-Apr-2025
Version number	9