Cellosaurus cell line LB5871-LYMP (CVCL

Cellosaurus LB5871-LYMP (CVCL_WV42)

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Cell line name

LB5871-LYMP

Accession

CVCL_WV42

Resource Identification Initiative

To cite this cell line use: LB5871-LYMP (RRID:CVCL_WV42)

Comments

Doubling time: 62 hours (PubMed=30277098); ~70 hours (DSMZ=ACC-869).
Derived from site: In situ; Cervical lymph node; UBERON=UBERON_0002429.

Sequence variations

Gene fusion; HGNC; HGNC:990; BCL2 + HGNC; HGNC:5477; IGH; Name(s)=IGH-BCL2 (PubMed=30277098).
Gene fusion; HGNC; HGNC:5477; IGH + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGH (PubMed=30277098).
Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Pro2139fs (c.6415_6424delCCCCCCTTCA); Zygosity=Heterozygous (PubMed=30277098).
Mutation; HGNC; HGNC:3373; EP300; Simple; p.Tyr1467Asp (c.4399T>G); Zygosity=Heterozygous (PubMed=30277098).
Mutation; HGNC; HGNC:11912; TNFRSF14; Simple; p.Trp7Ter (c.20G>A); Zygosity=Heterozygous (PubMed=30277098).
Mutation; HGNC; HGNC:11912; TNFRSF14; Simple; p.Ala194fs (c.578dup); Zygosity=Heterozygous (PubMed=30277098).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Arg (c.526T>C); ClinVar=VCV000376573; Zygosity=Hemizygous (PubMed=30277098).

Disease

High grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements (NCIt: C125904)
High grade B-cell lymphoma with MYC and/or BCL2 and/or BCL6 rearrangement (ORDO: Orphanet_480541)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

64Y

Category

Cancer cell line

STR profile

Source(s): DSMZ=ACC-869; PubMed=30277098

Markers:

Amelogenin	X
CSF1PO	10,12
D2S1338	17
D3S1358	16,17 (DSMZ=ACC-869) 17 (PubMed=30277098)
D5S818	11,13
D7S820	8,10
D8S1179	8,13
D13S317	11,13
D16S539	9,11
D18S51	12,16
D19S433	14
D21S11	29,30
FGA	22,25
Penta D	9,10 (DSMZ=ACC-869) 10 (PubMed=30277098)
Penta E	7,11 (PubMed=30277098) 11 (DSMZ=ACC-869)
TH01	7,9.3
TPOX	8
vWA	14,15

Publications

PubMed=30277098; DOI=10.1080/10428194.2018.1508663
Marie-Sophie Dheur, Helene A. Poirel, Genevieve Ameye, Gaelle Tilman, Pascale Saussoy, Jean-Philippe Defour, Alessandra Camboni, Eric Van Den Neste, Pierre G. Coulie, Nicolas van Baren;
Characterization of two new high-grade B-cell lymphoma cell lines with MYC and BCL2 rearrangements that are suitable for in vitro drug sensitivity studies.
Leuk. Lymphoma 60:1043-1052(2019)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-869

Cell line databases/resources

cancercelllines; CVCL_WV42
DSMZCellDive; ACC-869

Encyclopedic resources

Wikidata; Q95981508

Entry history

Entry creation

05-Jul-2019

Last entry update

19-Dec-2024

Version number