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Cellosaurus SJG-6 (CVCL_WV08)

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Cell line name SJG-6
Synonyms SJG-006
Accession CVCL_WV08
Resource Identification Initiative To cite this cell line use: SJG-6 (RRID:CVCL_WV08)
Comments Omics: Genomics; Whole exome sequencing.
Miscellaneous: STR profile from personal communication of Broad, Simon.
Derived from site: In situ; Oral cavity, alveolar ridge; UBERON=UBERON_0004103.
Sequence variations
  • Mutation; HGNC; HGNC:1509; CASP8; Simple; p.His278Tyr (c.832C>T); Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Glu833Ter (c.2497G>T); Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Ser3065Ter (c.9194C>G); Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Gln3524Ter (c.10570C>T); Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Cys312Ter (c.936C>A); Zygosity=Heterozygous (CelloPub=CLPUB00517; PubMed=27693639).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Trp1843Ter (c.5529G>A); Zygosity=Heterozygous (CelloPub=CLPUB00517; PubMed=27693639).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gln171Ter (c.511C>T); ClinVar=VCV000189411; Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu201Gln (c.601G>C); Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly209Glu (c.626G>A); Zygosity=Unspecified (PubMed=27693639).
Disease Alveolar ridge squamous cell carcinoma (NCIt: C170774)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO10
D3S135814,15
D5S81812,13
D7S82010
D8S117913
D13S31712
D16S53912
D18S5115,16
D21S1129,30
FGA19,24
Penta D10,12
Penta E7,13
TH016,9.3
TPOX10,11
vWA17,19

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Publications

CLPUB00518
Stephen J. Goldie;
Studies of FRMD4A in two models of squamous cell carcinoma.
Thesis PhD (2011); University of Cambridge; Cambridge; United Kingdom

PubMed=27693639; DOI=10.1016/j.canlet.2016.09.014; PMCID=PMC5090049
Tyler F. Hayes, Nathan Benaich, Stephen J. Goldie, Kalle Sipila, Ashley Ames-Draycott, Wen-Jun Cai, Guang-Liang Yin, Fiona Mary Watt;
Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.
Cancer Lett. 383:106-114(2016)

CLPUB00517
Ashley Jane Pritchard;
Correlating genetic change with changes in cell behaviour in squamous cell carcinoma of the head and neck (SCCHN). Focus on inactivating NOTCH1 mutations.
Thesis PhD (2018); King's College London; London; United Kingdom

Cross-references
Cell line databases/resources cancercelllines; CVCL_WV08
Encyclopedic resources Wikidata; Q98132636
Entry history
Entry creation05-Jul-2019
Last entry update10-Apr-2025
Version number11