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Cellosaurus HL-CZ (CVCL_WU73)

[Text version]
Cell line name HL-CZ
Accession CVCL_WU73
Resource Identification Initiative To cite this cell line use: HL-CZ (RRID:CVCL_WU73)
Comments Problematic cell line: Contaminated. Shown to be a K-562 derivative (BCRC=60043). Originally thought to originate from a 50 year old male patient with a acute T-cell leukemia.
Population: Caucasian.
Doubling time: 22-26 hours (CelloPub=CLPUB00515).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Web pages Info; BCRC; -; https://www.bcrc.firdi.org.tw/attach/2019-05-28/a.pdf
Publications

CLPUB00515
Wu-Tse Liu, Shu-Chu Chen, Ning Lee, Sai-Koong Tan, Shiow-Feng Liu, Po Dunn, Kenneth S.-S. Chang;
Establishment and characterization of a cell line of monocytic origin, HL-CZ, from human leukemia.
J. Biomed. Lab. Sci. 4:284-292(1989)

PubMed=1913629; DOI=10.1016/0304-3835(91)90051-I
Kenneth S.-S. Chang, W.-T. Liu, Steven F. Josephs;
Regulation of cellular trans-activating activities in two different promonocytic leukemia cell lines.
Cancer Lett. 60:75-83(1991)

PubMed=2063953; DOI=10.4269/ajtmh.1991.44.494
Wu-Tse Liu, Chich-Liang Chen, Susan Shin-Jung Lee, Chien-Chen Chan, Fu-Luen Lo, Ying-Chin Ko;
Isolation of dengue virus with a human promonocyte cell line.
Am. J. Trop. Med. Hyg. 44:494-499(1991)

CLPUB00516
Chien-Whei Lieu, Wu-Tse Liu, Kuang-Hui Sun, Sheng-Yuan Wang;
Some special characteristics of the novel human promonocyte cell line, HL-CZ.
J. Biomed. Lab. Sci. 5:196-204(1993)

CLPUB00514
Xuan-Hao Cheng;
Screening for differentially expressed genes in dengue infection under antibody dependent enhancement conditions.
Thesis MSc (2010); National University of Singapore; Singapore; Singapore

PubMed=25073113; DOI=10.1016/j.bbrc.2014.07.090; PMCID=PMC7092860
Sheng-Fan Wang, Sung-Pin Tseng, Chia-Hung Yen, Jyh-Yuan Yang, Ching-Han Tsao, Chun-Wei Shen, Kuan-Hsuan Chen, Fu-Tong Liu, Wu-Tse Liu, Yi-Ming Arthur Chen, Jason C. Huang;
Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins.
Biochem. Biophys. Res. Commun. 451:208-214(2014)

Cross-references
Cell line collections (Providers) BCRC; 60043 - Discontinued
Encyclopedic resources Wikidata; Q94211712
Entry history
Entry creation05-Jul-2019
Last entry update10-Apr-2025
Version number14