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Cellosaurus 5F11 (CVCL_WT46)

[Text version]
Cell line name 5F11
Accession CVCL_WT46
Resource Identification Initiative To cite this cell line use: 5F11 (RRID:CVCL_WT46)
Comments Biotechnology: The monoclonal antibody produced by this hybridoma was developed by Medarex into a therapeutic mAB known as Iratumumab (MDX-060) to be used in the treatment of oncological diseases such as relapsed refractory CD30-positive lymphoma including Hodgkin's disease.
Monoclonal antibody isotype: IgG1, kappa.
Monoclonal antibody target: UniProtKB; P28908; Human TNFRSF8/CD30.
Miscellaneous: As the immunized splenic B-cells are from HuMAb mice the produced mAB is of human origin.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_4032 (P3X63Ag8.653)
Category Hybridoma
Publications

PubMed=12881320; DOI=10.1182/blood-2003-02-0515
Borchmann P., Treml J.F., Hansen H., Gottstein C., Schnell R., Staak O., Zhang H.-F., Davis T., Keler T., Diehl V., Graziano R.F., Engert A.
The human anti-CD30 antibody 5F11 shows in vitro and in vivo activity against malignant lymphoma.
Blood 102:3737-3742(2003)

Cross-references
Biological sample resources ABCD; ABCD_AD047
Encyclopedic resources Wikidata; Q93308285
Entry history
Entry creation05-Jul-2019
Last entry update21-Mar-2023
Version number5