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Cellosaurus Tyler1 (CVCL_WS64)

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Cell line name Tyler1
Synonyms TYLER1
Accession CVCL_WS64
Resource Identification Initiative To cite this cell line use: Tyler1 (RRID:CVCL_WS64)
Comments Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; VGNC; VGNC:38093; ARID1A; Simple; p.Ala901fs (c.2700_2701insA); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; VGNC:38297; ATRX; Simple; p.Cys1810Ter (c.5430T>A); Zygosity=Homozygous (PubMed=31175136).
  • Mutation; VGNC; VGNC:38514; BRAF; Simple; p.Val588Glu (c.1763T>A); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine transitional cell carcinoma (NCIt: C128126)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Beagle; VBO=VBO_0200131.
Originate from same individual CVCL_WS65 ! Tyler2
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): PubMed=31175136

Markers:
Dog FHC2010239
Dog FHC2054151
Dog FHC2079271,275
Dog PEZ1119
Dog PEZ12263,281
Dog PEZ20176,180
Dog PEZ3134
Dog PEZ5107,111
Dog PEZ6175,183
Dog PEZ8227,236

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Publications

DOI=10.1158/1538-7445.AM2012-5258
Dodd G. Sledge, Matti Kiupel, Nicole Madrill, Elizabeth A. McNiel;
Characterization of canine lower urinary tract carcinoma cell lines with variable DNA mismatch repair proficiency derived from a single tumor.
Cancer Res. 72 Suppl. 8:5258-5258(2012)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748
Sunetra Das, Rupa Idate, Kathryn E. Cronise, Daniel L. Gustafson, Dawn L. Duval;
Identifying candidate druggable targets in canine cancer cell lines using whole-exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Cross-references
Encyclopedic resources Wikidata; Q98133703
Entry history
Entry creation05-Jul-2019
Last entry update10-Apr-2025
Version number9