Cellosaurus cell line LN-2683GS (CVCL

Cellosaurus LN-2683GS (CVCL_WS30)

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Cell line name

LN-2683GS

Accession

CVCL_WS30

Resource Identification Initiative

To cite this cell line use: LN-2683GS (RRID:CVCL_WS30)

Comments

Characteristics: Glioma-derived sphere line. Tumorigenic in nude mice.
Omics: Genomics; DNA methylation analysis.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Brain, right parietal lobe; UBERON=UBERON_0002803.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=22570425).
Mutation; HGNC; HGNC:9588; PTEN; Unexplicit; Ex1-9del; Zygosity=Heterozygous (PubMed=22570425).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu224Lys (c.670G>A); ClinVar=VCV000480767; Zygosity=Heterozygous (PubMed=22570425).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro250Leu (c.749C>T); ClinVar=VCV000420136; Zygosity=Heterozygous (PubMed=22570425).

Disease

Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

51Y

Category

Cancer cell line

STR profile

Source(s): PubMed=22570425

Markers:

Amelogenin	X
CSF1PO	11,12
D3S1358	15
D5S818	10,12
D7S820	11
D8S1179	10,14
D13S317	8,10
D16S539	12
D18S51	16,19
D21S11	30,31
FGA	22,23.2
Penta D	13,14
Penta E	10
TH01	7,9.3
TPOX	8,12
vWA	14,18

Publications

PubMed=21097691; DOI=10.1158/1078-0432.CCR-10-1931
Davide Sciuscio, Annie-Claire Diserens, Kristof van Dommelen, Danielle Martinet, Greg Jones, Robert-Charles Janzer, Claudio Pollo, Marie-France Hamou, Bernd Kaina, Roger Stupp, Marc Levivier, Monika E. Hegi;
Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.
Clin. Cancer Res. 17:255-266(2011)

PubMed=22570425; DOI=10.1093/neuonc/nos072; PMCID=PMC3367844
Pierre Bady, Annie-Claire Diserens, Vincent Castella, Stefanie Kalt, Karl Heinimann, Marie-France Hamou, Mauro Delorenzi, Monika E. Hegi;
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=25622821; DOI=10.1186/s13059-015-0583-7; PMCID=PMC4342872
Sebastian Kurscheid, Pierre Bady, Davide Sciuscio, Ivana Samarzija, Tal Shay, Irene Vassallo, Wim Van Criekinge, Roy Thomas Daniel, Martin J. van den Bent, Christine Marosi, Michael Weller ...Show all 16 authors... , Warren P. Mason, Eytan Domany, Roger Stupp, Mauro Delorenzi, Monika E. Hegi; Show fewer authors
Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma.
Genome Biol. 16:16.1-16.15(2015)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_WS30

Encyclopedic resources

Wikidata; Q95982666

Gene expression databases

GEO; GSM1469041
GEO; GSM2794467
GEO; GSM2794468
GEO; GSM2794469
GEO; GSM2889488

Entry history

Entry creation

05-Jul-2019

Last entry update

10-Apr-2025

Version number