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Cellosaurus OCT-1 (CVCL_WN86)

[Text version]
Cell line name OCT-1
Synonyms Oct-1; Osteocalcin-T antigen clone #1
Accession CVCL_WN86
Resource Identification Initiative To cite this cell line use: OCT-1 (RRID:CVCL_WN86)
Comments Doubling time: 27.3 hours (CelloPub=CLPUB00625).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Bone, calvaria; UBERON=UBERON_0004339.
Cell type: Osteoblast; CL=CL_0000062.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: (C57BL/6J x BALB/cJ) F2 rat Bgla promoter T-Ag transgenic.
Originate from same individual CVCL_WN87 ! OCT-2
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

CLPUB00508
Di Chen, Hong Chen, Jian Q. Feng, Jolene J. Windle, Barbara A. Koop, Marie A. Harris, Lynda Faye Bonewald, Brendan F. Boyce, John M. Wozney, Gregory Robert Mundy, Stephen E. Harris;
Osteoblastic cell lines derived from a transgenic mouse containing the osteocalcin promoter driving SV40 T-antigen.
Mol. Cell. Differ. 3:193-212(1995)

PubMed=9421234; DOI=10.1359/jbmr.1997.12.12.2014
Yoichi Kato, Jolene J. Windle, Barbara A. Koop, Gregory Robert Mundy, Lynda Faye Bonewald;
Establishment of an osteocyte-like cell line, MLO-Y4.
J. Bone Miner. Res. 12:2014-2023(1997)

CLPUB00625
Patrick Lau, Christine Elisabeth Hellweg, Stefan Kirchner, Andrea Arenz, Christa Baumstark-Khan, Gerda Horneck;
Induction of DNA-strand breaks after X-irradiation in murine bone cells of various differentiation capacities.
(In conference) Abstracts of the 35th COSPAR scientific assembly; pp.1960-1960; Committee on Space Research; Paris; France (2004)

PubMed=16738320; DOI=10.1128/mcb.02120-05; PMCID=PMC1489126
Ke-Qin Zhang, Cielo Barragan-Adjemian, Ling Ye, Shiva Kotha, Mark Dallas, Yong-Bo Lu, Shu-Jie Zhao, Marie Harris, Stephen E. Harris, Jian Q. Feng, Lynda Faye Bonewald;
E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation.
Mol. Cell. Biol. 26:4539-4552(2006)

PubMed=20232074; DOI=10.1007/s00411-010-0272-6
Patrick Lau, Christa Baumstark-Khan, Christine Elisabeth Hellweg, Gunther Reitz;
X-irradiation-induced cell cycle delay and DNA double-strand breaks in the murine osteoblastic cell line OCT-1.
Radiat. Environ. Biophys. 49:271-280(2010)

Cross-references
Encyclopedic resources Wikidata; Q98128327
Entry history
Entry creation05-Jul-2019
Last entry update14-Aug-2025
Version number8