Cellosaurus cell line G-OF4iPS12 (CVCL

Cellosaurus G-OF4iPS12 (CVCL_WL21)

Cross-references
Cell line name	G-OF4iPS12
Accession	CVCL_WL21
Resource Identification Initiative	To cite this cell line use: G-OF4iPS12 (RRID:CVCL_WL21)
Comments	Derived from site: In situ; Oral cavity, oral mucosa; UBERON=UBERON_0003729.
Sequence variations	Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Leu506Arg (c.1517T>G); Zygosity=Heterozygous (PubMed=28915250).
Disease	Nevoid basal cell carcinoma syndrome (NCIt: C2892) Gorlin syndrome (ORDO: Orphanet_377)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	20-25Y
Category	Induced pluripotent stem cell
Publications	PubMed=28915250; DOI=10.1371/journal.pone.0184702; PMCID=PMC5600381 Shoko Onodera, Akiko Saito, Daigo Hasegawa, Nana Morita, Katsuhito Watanabe, Takeshi Nomura, Takahiko Shibahara, Shinsuke Ohba, Akira Yamaguchi, Toshifumi Azuma; Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype. PLoS ONE 12:e0184702.1-e0184702.14(2017) PubMed=29088246; DOI=10.1371/journal.pone.0186879; PMCID=PMC5663396 Daigo Hasegawa, Hiromi Ochiai-Shino, Shoko Onodera, Takashi Nakamura, Akiko Saito, Takeshi Onda, Katsuhito Watanabe, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Kenjiro Kosaki ...Show all 14 authors... , Akira Yamaguchi, Takahiko Shibahara, Toshifumi Azuma; Show fewer authors Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction. PLoS ONE 12:e0186879.1-e0186879.17(2017)
Encyclopedic resources	Wikidata; Q93558133
Entry history
Entry creation	24-May-2019
Last entry update	19-Dec-2024
Version number	9