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Cellosaurus RBM1-IT4 (CVCL_WK99)

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Cell line name RBM1-IT4
Synonyms Renal cancer Bone Metastasis 1-Intra Tibial 4
Accession CVCL_WK99
Resource Identification Initiative To cite this cell line use: RBM1-IT4 (RRID:CVCL_WK99)
Comments Characteristics: Established from a xenograft obtained by intratibial injection of the parent cell line in nude mice.
Derived from site: Metastatic; Bone, left humerus; UBERON=UBERON_0000976.
Sequence variations
  • Mutation; HGNC; HGNC:12687; VHL; Simple; p.Asp179Thrfs*21 (c.535delG); Zygosity=Hemizygous (PubMed=17332933).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5T98 (RBM1 [Human renal cell carcinoma])
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=12131367; DOI=10.1016/S0022-5347(05)64743-X
Kristy L. Weber, Sen Pathak, Asha S. Multani, Janet E. Price;
Characterization of a renal cell carcinoma cell line derived from a human bone metastasis and establishment of an experimental nude mouse model.
J. Urol. 168:774-779(2002)

PubMed=12782601
Kristy L. Weber, Michele Doucet, Janet E. Price, Cheryl Baker, Sun Jin Kim, Isaiah Joshua Fidler;
Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice.
Cancer Res. 63:2940-2947(2003)

PubMed=17332933; DOI=10.3892/ijo.30.4.937
Takashi Karashima, Keiji Inoue, Satoshi Fukata, Tatsuo Iiyama, Atsushi Kurabayashi, Chiaki Kawada, Taro Shuin;
Blockade of the vascular endothelial growth factor-receptor 2 pathway inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the kidney but not in the bone of nude mice.
Int. J. Oncol. 30:937-945(2007)

Cross-references
Encyclopedic resources Wikidata; Q98128844
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number8