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Cellosaurus MCF-7 R27 (CVCL_WK73)

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Cell line name MCF-7 R27
Synonyms R27
Accession CVCL_WK73
Resource Identification Initiative To cite this cell line use: MCF-7 R27 (RRID:CVCL_WK73)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
HLA typing Source: PubMed=9023415
Class I
HLA-AA*02:01
HLA-BB*44:02
HLA-CC*05:01
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=7228867; DOI=10.1016/S0021-9258(19)69359-2
Hajime Nawata, Diane A. Bronzert, Marc E. Lippman;
Isolation and characterization of a tamoxifen-resistant cell line derived from MCF-7 human breast cancer cells.
J. Biol. Chem. 256:5016-5021(1981)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Naoko Seki, Tomoaki Hoshino, Megumi Kikuchi, Akihiro Hayashi, Kyogo Itoh;
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WK73
Encyclopedic resources Wikidata; Q95986105
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number9