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Cellosaurus K562/DAC (CVCL_WI19)

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Cell line name K562/DAC
Accession CVCL_WI19
Resource Identification Initiative To cite this cell line use: K562/DAC (RRID:CVCL_WI19)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_50131; 5-aza-2'-deoxycytidine (Decitabine).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=30793488; DOI=10.1111/jcmm.14221; PMCID=PMC6484323
Xiang-Mei Wen, Ting-Juan Zhang, Ji-Chun Ma, Jing-Dong Zhou, Zi-Jun Xu, Xiao-Wen Zhu, Qian Yuan, Run-Bi Ji, Qin Chen, Zhao-Qun Deng, Jiang Lin, Jun Qian;
Establishment and molecular characterization of decitabine-resistant K562 cells.
J. Cell. Mol. Med. 23:3317-3324(2019)

Cross-references
Encyclopedic resources Wikidata; Q94335820
Entry history
Entry creation24-May-2019
Last entry update10-Apr-2025
Version number13