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Cellosaurus AKG HR (CVCL_WH03)

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Cell line name AKG HR
Accession CVCL_WH03
Resource Identification Initiative To cite this cell line use: AKG HR (RRID:CVCL_WH03)
Comments Doubling time: 33 hours (PubMed=26919099).
Selected for resistance to: DrugBank; DB00072; Trastuzumab (Herceptin).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Leu1061Pro (c.3182T>C); ClinVar=VCV000134079; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Pro1170Ala (c.3508C>G); ClinVar=VCV000134082; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:3431; ERBB3; Simple; p.Thr757Lys (c.2270C>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Unspecified (from parent cell line).
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_WH02 (AKG)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=26919099; DOI=10.18632/oncotarget.7575; PMCID=PMC4951299
Chiara Arienti, Michele Zanoni, Sara Pignatta, Alberto Del Rio, Silvia Carloni, Michela Tebaldi, Gianluca Tedaldi, Anna Tesei;
Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer.
Oncotarget 7:18424-18439(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WH03
Encyclopedic resources Wikidata; Q93324025
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number9