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Cellosaurus AOXlar7y (CVCL_WC97)

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Cell line name AOXlar7y
Synonyms Acipenser OXyrinchus larvae no7, trypsin-digestion
Accession CVCL_WC97
Resource Identification Initiative To cite this cell line use: AOXlar7y (RRID:CVCL_WC97)
Comments Group: Fish cell line.
Characteristics: Optimal growth temperature is 25 Celsius (PubMed=38334662).
Characteristics: Increased proliferation rates after adapting to a temperature of 28 Celsius (PubMed=41104012).
Doubling time: 110 hours (PubMed=30862517); 30-50 hours (Note=In 2%, 5% or 10% FBS and/or in the presence of several growth factors and cytokines) (PubMed=41104012).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Whole larva; UBERON=UBERON_0002548.
Species of origin Acipenser oxyrinchus (Atlantic sturgeon) (NCBI Taxonomy: 36177)
Sex of cell Sex unspecified
Age at sampling Larval stage
Category Spontaneously immortalized cell line
Publications

DOI=10.3354/ab00383
Bianka Grunow, Sarah Noglick, Charli Kruse, Marina Gebert;
Isolation of cells from Atlantic sturgeon Acipenser oxyrinchus oxyrinchus and optimization of culture conditions.
Aquat. Biol. 14:67-75(2011)

PubMed=30862517; DOI=10.1016/j.fsi.2019.03.014
Elena Santidrian Yebra-Pimentel, Marina Gebert, Hans J. Jansen, Susanne A. Jong-Raadsen, Ron P.H. Dirks;
Deep transcriptome analysis of the heat shock response in an Atlantic sturgeon (Acipenser oxyrinchus) cell line.
Fish Shellfish Immunol. 88:508-517(2019)

PubMed=34822677; DOI=10.3390/toxics9110286; PMCID=PMC8618082
Bianka Grunow, George Philipp Franz, Katrin Tonissen;
In vitro fish models for the analysis of ecotoxins and temperature increase in the context of global warming.
Toxics 9:286.1-286.15(2021)

PubMed=38334662; DOI=10.3390/cells13030269; PMCID=PMC10854621
Philipp Lutze, Julia Brenmoehl, Stephanie Tesenvitz, Daniela Ohde, Heike Wanka, Zianka Meyer, Bianka Grunow;
Effects of temperature adaptation on the metabolism and physiological properties of sturgeon fish larvae cell line.
Cells 13:269-269(2024)

PubMed=41104012; DOI=10.3389/ftox.2025.1636776; PMCID=PMC12521256
Valeria Di Leonardo, Julia Brenmoehl, Heike Wanka, Bianka Grunow;
Proliferation and metabolic activity of the Atlantic sturgeon cell line AOXlar7y under short-term serum-reduced conditions, and the effect of stimulation with growth factors and cytokines.
Front. Toxicol. 7:1636776-1636776(2025)

Cross-references
Encyclopedic resources Wikidata; Q93325377
Entry history
Entry creation24-May-2019
Last entry update31-Mar-2026
Version number8