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Cellosaurus PER-490 (CVCL_W986)

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Cell line name PER-490
Synonyms PER-490A
Accession CVCL_W986
Secondary accession CVCL_IY98
Resource Identification Initiative To cite this cell line use: PER-490 (RRID:CVCL_W986)
Comments Doubling time: 97 hours (PubMed=17117183); 72 hours (PubMed=27443263).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Miscellaneous: Sampling site from personal communication of Kotecha, Rishi S.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Disease Infant acute lymphoblastic leukemia with MLL rearrangement (NCIt: C122617)
Acute lymphoblastic leukemia (ORDO: Orphanet_513)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 9D
Category Cancer cell line
STR profile Source(s): PubMed=17117183; PubMed=27443263; PubMed=33937032

Markers:
AmelogeninX
CSF1PO11
D2S133823,26
D3S135815,17
D5S81811,12
D7S82010,11
D8S117912,14
D13S31711,12
D16S53911,12
D18S5112,17
D19S43313,15
D21S1131,33.2
FGA22,24
TH016,9.3
TPOX8
vWA15,17

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Publications

PubMed=12883040
Ursula R. Kees, Jette Ford, Marcia Watson, Ashleigh R. Murch, Markus Ringner, Robert L. Walker, Paul S. Meltzer;
Gene expression profiles in a panel of childhood leukemia cell lines mirror critical features of the disease.
Mol. Cancer Ther. 2:671-677(2003)

PubMed=17117183; DOI=10.1038/sj.bjc.6603447; PMCID=PMC2360743
Alex H. Beesley, Misty-Lee Palmer, Jette Ford, Richard E. Weller, Aaron J. Cummings, Joseph R. Freitas, Martin J. Firth, Kanchana U. Perera, Nick H. de Klerk, Ursula R. Kees;
Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines.
Br. J. Cancer 95:1537-1544(2006)

PubMed=27443263; DOI=10.1038/leu.2016.165; PMCID=PMC5220136
Mark Nicholas Cruickshank, Jette Ford, Laurence C. Cheung, Jasmin Heng, Sajla Singh, John Wells, Timothy W. Failes, Greg M. Arndt, Nicholas Smithers, Rabinder Kumar Prinjha, Denise Anderson ...Show all 18 authors... , Kim Warwick Carter, Alexander M. Gout, Timo Lassmann, John O'Reilly, Catherine Helen Cole, Rishi S. Kotecha, Ursula R. Kees; Show fewer authors
Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin.
Leukemia 31:40-50(2017)

PubMed=33937032; DOI=10.3389/fonc.2021.631594; PMCID=PMC8082024
Laurence C. Cheung, Rebecca de Kraa, Joyce Oommen, Grace-Alyssa Chua, Sajla Singh, Anastasia M. Hughes, Emanuela Ferrari, Jette Ford, Sung K. Chiu, Ronald W. Stam, Ursula R. Kees ...Show all 13 authors... , Sebastien Malinge, Rishi S. Kotecha; Show fewer authors
Preclinical evaluation of carfilzomib for infant KMT2A-rearranged acute lymphoblastic leukemia.
Front. Oncol. 11:631594.1-631594.13(2021)

Cross-references
Encyclopedic resources Wikidata; Q54947203
Entry history
Entry creation17-Jul-2014
Last entry update10-Apr-2025
Version number12