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Cellosaurus PER-485 (CVCL_W984)

[Text version]
Cell line name PER-485
Synonyms PER-485A
Accession CVCL_W984
Secondary accession CVCL_IY97
Resource Identification Initiative To cite this cell line use: PER-485 (RRID:CVCL_W984)
Comments Doubling time: 53 hours (PubMed=17117183); 48 hours (PubMed=27443263).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Miscellaneous: Sampling site from personal communication of Kotecha, Rishi S.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Disease Infant acute lymphoblastic leukemia with MLL rearrangement (NCIt: C122617)
Acute lymphoblastic leukemia (ORDO: Orphanet_513)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A8JU ! PER-494
Sex of cell Female
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): PubMed=17117183; PubMed=27443263; PubMed=33937032

Markers:
AmelogeninX
CSF1PO11
D2S133824,25
D3S135816,18
D5S81812
D7S82010,11
D8S117913,15
D13S3178,12
D16S53911
D18S5112,16
D19S43314,16.2
D21S1130.2,31.2
FGA20,24
TH016,9
TPOX9
vWA15,16

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Publications

PubMed=12883040
Kees U.R., Ford J., Watson M., Murch A.R., Ringner M., Walker R.L., Meltzer P.S.
Gene expression profiles in a panel of childhood leukemia cell lines mirror critical features of the disease.
Mol. Cancer Ther. 2:671-677(2003)

PubMed=17117183; DOI=10.1038/sj.bjc.6603447; PMCID=PMC2360743
Beesley A.H., Palmer M.-L., Ford J., Weller R.E., Cummings A.J., Freitas J.R., Firth M.J., Perera K.U., de Klerk N.H., Kees U.R.
Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines.
Br. J. Cancer 95:1537-1544(2006)

PubMed=27443263; DOI=10.1038/leu.2016.165; PMCID=PMC5220136
Cruickshank M.N., Ford J., Cheung L.C., Heng J., Singh S., Wells J., Failes T.W., Arndt G.M., Smithers N., Prinjha R.K., Anderson D., Carter K.W., Gout A.M., Lassmann T., O'Reilly J., Cole C.H., Kotecha R.S., Kees U.R.
Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin.
Leukemia 31:40-50(2017)

PubMed=33937032; DOI=10.3389/fonc.2021.631594; PMCID=PMC8082024
Cheung L.C., de Kraa R., Oommen J., Chua G.-A., Singh S., Hughes A.M., Ferrari E., Ford J., Chiu S.K., Stam R.W., Kees U.R., Malinge S., Kotecha R.S.
Preclinical evaluation of carfilzomib for infant KMT2A-rearranged acute lymphoblastic leukemia.
Front. Oncol. 11:631594.1-631594.13(2021)

Cross-references
Encyclopedic resources Wikidata; Q54947199
Entry history
Entry creation17-Jul-2014
Last entry update10-Apr-2025
Version number13