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Cellosaurus MCF-7/AZ (CVCL_W971)

[Text version]
Cell line name MCF-7/AZ
Synonyms MCF-7AZ
Accession CVCL_W971
Resource Identification Initiative To cite this cell line use: MCF-7/AZ (RRID:CVCL_W971)
Comments Population: Caucasian.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=1648947; DOI=10.1038/bjc.1991.191; PMCID=PMC1972531
Marc E. Bracke, Nicolas A.F. Van Larebeke, Barbara M. Vyncke, Marc M. Mareel;
Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro.
Br. J. Cancer 63:867-872(1991)

PubMed=8528519; DOI=10.1007/BF02634317
Joris J. Deman, Nicolas A.F. Van Larebeke, Erik A. Bruyneel, Marc E. Bracke, Stefan Joris Vermeulen, Krist'l M. Vennekens, Marc M. Mareel;
Removal of sialic acid from the surface of human MCF-7 mammary cancer cells abolishes E-cadherin-dependent cell-cell adhesion in an aggregation assay.
In Vitro Cell. Dev. Biol. Anim. 31:633-639(1995)

PubMed=22161839; DOI=10.1387/ijdb.113336ld
Lara Derycke, Christophe Stove, Anne-Sophie Vercoutter-Edouart, Olivier De Wever, Laurent Dolle, Nathalie Colpaert, Herman Depypere, Jean-Claude Michalski, Marc E. Bracke;
The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells.
Int. J. Dev. Biol. 55:835-840(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_W971
Encyclopedic resources Wikidata; Q54904357
Polymorphism and mutation databases Cosmic; 2036668
Entry history
Entry creation17-Jul-2014
Last entry update19-Dec-2024
Version number16