Cellosaurus cell line THJ-11T (CVCL

Cellosaurus THJ-11T (CVCL_W919)

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Cell line name

THJ-11T

Synonyms

THJ11T

Accession

CVCL_W919

Resource Identification Initiative

To cite this cell line use: THJ-11T (RRID:CVCL_W919)

Comments

Doubling time: 30 hours (PubMed=20810568).
Miscellaneous: STR profile and age of donor from personal communication of Marlow, Laura A.
Caution: Cell line wrongly indicated as being female in figure 2A of PubMed=20810568.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.

Sequence variations

Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=20810568; PubMed=23833040).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040).

Disease

Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

46Y

Category

Cancer cell line

STR profile

Source(s): Direct_author_submission

Markers:

Amelogenin	X,Y
CSF1PO	12
D3S1358	14,17
D5S818	13
D7S820	9
D8S1179	13
D13S317	8,13
D16S539	12,13
D18S51	12,14
FGA	21,24
TH01	5,6
TPOX	8,11
vWA	16,17

Publications

PubMed=20810568; DOI=10.1210/jc.2010-1421; PMCID=PMC2999968
Laura A. Marlow, Jaclyn M. D'Innocenzi, Yi-Lin Zhang, Stephen Davis Rohl, Simon J. Cooper, Thomas Joseph Sebo, Clive Grant, Bryan McIver, Jan Lee Kasperbauer, J. Trad Wadsworth, John D. Casler ...Show all 24 authors... , Pamela W. Kennedy, William Edward Highsmith Jr., Owen Clark, Dragana Milosevic, Brian C. Netzel, Kendall W. Cradic, Shilpi Arora, Christian Beaudry, Stefan K.G. Grebe, Marc L. Silverberg, David O. Azorsa, Robert Christian Smallridge, John Alton Copland 3rd; Show fewer authors
Detailed molecular fingerprinting of four new anaplastic thyroid carcinoma cell lines and their use for verification of RhoB as a molecular therapeutic target.
J. Clin. Endocrinol. Metab. 95:5338-5347(2010)

PubMed=23724124; DOI=10.1371/journal.pone.0065095; PMCID=PMC3665717
Wen Li, Ashley N. Reeb, William A. Sewell, George Elhomsy, Reigh-Yi Lin;
Phenotypic characterization of metastatic anaplastic thyroid cancer stem cells.
PLoS ONE 8:e65095.1-e65095.10(2013)

PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971
Inigo Landa, Ian Ganly, Timothy A. Chan, Norisato Mitsutake, Michiko Matsuse, Tihana Ibrahimpasic, Ronald A. Ghossein, James Alexander Fagin;
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

Cross-references

Cell line collections (Providers)

ABM; T8251

Cell line databases/resources

cancercelllines; CVCL_W919

Encyclopedic resources

Wikidata; Q54972300

Polymorphism and mutation databases

Cosmic; 2054093

Entry history

Entry creation

17-Jul-2014

Last entry update

10-Apr-2025

Version number