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Cellosaurus MDA-T41 (CVCL_W914)

[Text version]
Cell line name MDA-T41
Accession CVCL_W914
Resource Identification Initiative To cite this cell line use: MDA-T41 (RRID:CVCL_W914)
Comments Population: Caucasian.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23833040; PubMed=25427145; PubMed=30737244).
  • Mutation; HGNC; 9884; RB1; Simple; p.Ile831Phe (c.2491A>T); Zygosity=Heterozygous (PubMed=30737244).
  • Mutation; HGNC; 11998; TP53; Simple; p.Phe19fs (c.56_65delTTTCAGACCT); Zygosity=Heterozygous (PubMed=30737244).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys176Phe (c.527G>T); ClinVar=VCV000376569; Zygosity=Heterozygous (PubMed=30737244).
Disease Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3352; PubMed=25427145; PubMed=30737244

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S8189,12
D7S8208,12
D13S3179,12
D16S53912
TH016
TPOX8
vWA15,16

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Publications

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=25427145; DOI=10.1210/jc.2014-2624
Henderson Y.C., Ahn S.-H., Ryu J., Chen Y.-Y., Williams M.D., El-Naggar A.K., Gagea M., Schweppe R.E., Haugen B.R., Lai S.Y., Clayman G.L.
Development and characterization of six new human papillary thyroid carcinoma cell lines.
J. Clin. Endocrinol. Metab. 100:E243-E252(2015)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. III, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-3352
Cell line databases/resources cancercelllines; CVCL_W914
Encyclopedic resources Wikidata; Q54904661
Polymorphism and mutation databases Cosmic; 2054114
Cosmic; 2612755
Entry history
Entry creation17-Jul-2014
Last entry update02-May-2024
Version number16