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Cellosaurus LAM1 (CVCL_W912)

[Text version]
Cell line name LAM1
Synonyms LAM-1; Lam-1
Accession CVCL_W912
Resource Identification Initiative To cite this cell line use: LAM1 (RRID:CVCL_W912)
Comments Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Left subcarinal lymph node; UBERON=UBERON_8480055.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=30737244).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Ile85Serfs*33 (c.249_252delGTCT) (p.Leu83fs); ClinVar=VCV000016693; Zygosity=Unspecified (PubMed=30737244).
  • Mutation; HGNC; HGNC:28958; NUP93; Simple; p.Gln15Ter (c.43C>T); Zygosity=Heterozygous (PubMed=30737244).
  • Mutation; HGNC; HGNC:9822; RAD51B; Simple; p.Gln270Ter (c.808C>T); Zygosity=Heterozygous (PubMed=30737244).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=30737244).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly154del (c.460_462delGGC); Zygosity=Homozygous (PubMed=30737244).
Disease Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): PubMed=30737244

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135815,17
D5S81812,13
D7S82010,11
D8S117912
D13S31710,11
D16S5398,12
D18S5115
FGA19,22
TH019.3,10
TPOX8
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=17199440; DOI=10.1089/thy.2006.16.1293
John Alton Copland 3rd, Laura A. Marlow, Sandra F. Williams, Stefan K.G. Grebe, Michelle L. Gumz, William J. Maples, Victor E. Silverman, Robert Christian Smallridge;
Molecular diagnosis of a BRAF papillary thyroid carcinoma with multiple chromosome abnormalities and rare adrenal and hypothalamic metastases.
Thyroid 16:1293-1302(2006)

PubMed=25675381; DOI=10.1210/jc.2014-2764; PMCID=PMC4422887
Christina A. von Roemeling, Laura A. Marlow, Anthony B. Pinkerton, Angela Crist, James Miller, Han W. Tun, Robert Christian Smallridge, John Alton Copland 3rd;
Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.
J. Clin. Endocrinol. Metab. 100:E697-E709(2015)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line collections (Providers) ABM; T8255
Cell line databases/resources cancercelllines; CVCL_W912
Encyclopedic resources Wikidata; Q54901909
Polymorphism and mutation databases Cosmic; 1054587
Entry history
Entry creation17-Jul-2014
Last entry update10-Apr-2025
Version number17